Fecal microbiota transplantation for treatment of non-alcoholic fatty liver disease: Mechanism, clinical evidence, and prospect

Figure 1 Homeostatic and disrupted gut-liver crosstalk, and mechanism of fecal microbiota transplantation for non-alcoholic fatty liver disease treatment. Left: Healthy/homeostatic condition; Middle: In non-alcoholic fatty liver disease (NAFLD), the intestinal barrier can be disrupted, which facilitates the translocation of microbes and microbial metabolites to the liver, thus promoting hepatic steatosis, inflammation and fibrosis; Right: Fecal microbiota transplantation is used to recover microbial diversity and abundance and restore homeostatic gut-liver crosstalk, and consequently attenuate the symptoms of NAFLD; FMT: Fecal microbiota transplantation.