Prognostic value of preoperative systemic immune-inflammation index/albumin for patients with hepatocellular carcinoma undergoing curative resection

Table 3 Univariate and multivariate Cox proportional hazards regression models for overall survival and recurrence-free survival

Variables	Overall survival				Recurrence-free survival
	Univariate		Multivariate		Univariate		Multivariate
	HR (95%CI)	P value	AHR (95%CI)	P value	HR (95%CI)	P value	AHR (95%CI)	P value
Sex
Female	Reference				Reference
Male	1.19 (0.95-1.50)	0.134			1.18 (0.97-1.42)	0.09
Age, years
≤ 60	Reference		Reference		Reference		Reference
> 60	0.70 (0.58-0.84)	< 0.001	0.79 (0.65-0.96)	0.017	0.73 (0.63-0.85)	< 0.001	0.77 (0.66-0.90)	0.001
Hepatitis B surface antigen
Negative	Reference		Reference		Reference		Reference
Positive	1.58 (1.24-2.01)	< 0.001	1.38 (1.07-1.79)	0.014	1.44 (1.19-1.75)	< 0.001	1.31 (1.07-1.61)	0.009
Alpha-fetoprotein, ng/mL
< 400	Reference		Reference		Reference		Reference
≥ 400	1.58 (1.32-1.91)	< 0.001	1.26 (1.04-1.52)	0.018	1.38 (1.18-1.63)	< 0.001	1.21 (1.02-1.43)	0.027
Alanine transaminase, IU/L
≤ 40	Reference		Reference		Reference		Reference
> 40	1.48 (1.26-1.75)	< 0.001	0.96 (0.79-1.17)	0.69	1.40 (1.21-1.60)	< 0.001	0.92 (0.78-1.08)	0.315
Aspartate transaminase, IU/L
≤ 40	Reference		Reference		Reference		Reference
> 40	2.19 (1.87-2.57)	< 0.001	1.31 (1.07-1.60)	0.007	2.08 (1.83-2.37)	< 0.001	1.47 (1.25-1.74)	< 0.001
Prothrombin time, second
≤ 13	Reference		Reference		Reference		Reference
> 13	1.41 (1.16-1.70)	< 0.001	1.18 (0.97-1.43)	0.073	1.25 (1.06-1.47)	0.007	1.08 (0.92-1.28)	0.352
Total bilirubin, μmol/L
≤ 32.4	Reference				Reference
> 32.4	1.00 (0.52-1.92)	0.992			1.02 (0.59-1.76)	0.953
Albumin-bilirubin grade
1	Reference		Reference		Reference		Reference
2	1.79 (1.51-2.12)	< 0.001	1.28 (1.07-1.60)	0.007	1.45 (1.25-1.68)	< 0.001	1.08 (0.93-1.27)	0.316
Tumor diameter, cm
< 5	Reference		Reference		Reference		Reference
≥ 5	3.13 (2.63-3.73)	< 0.001	2.12 (1.74-2.58)	< 0.001	2.48 (2.17-2.85)	< 0.001	1.85 (1.59-2.15)	< 0.001
Number of tumors
Single	Reference		Reference		Reference		Reference
Multiple	1.65 (1.37-1.99)	< 0.001	1.55 (1.27-1.87)	< 0.001	1.87 (1.60-2.19)	< 0.001	1.76 (1.50-2.07)	< 0.001
Hypertension
No	Reference		Reference		Reference		Reference
Yes	0.74 (0.58-0.94)	0.013	1.01 (0.79-1.30)	0.933	0.82 (0.68-0.98)	0.034	1.02 (0.84-1.24)	0.842
Diabetes
No	Reference				Reference
Yes	1.04 (0.78-1.38)	0.792			0.84 (0.65-1.09)	0.191
Cardiovascular disease
No	Reference				Reference
Yes	0.76 (0.39-1.47)	0.413			0.68 (0.38-1.20)	0.18
Anatomical resection
No	Reference		Reference		Reference
Yes	1.21 (1.03-1.41)	0.022	0.96 (0.82-1.14)	0.668	1.10 (0.96-1.26)	0.161
Major hepatectomy
No	Reference		Reference		Reference		Reference
Yes	2.13 (1.76-2.58)	< 0.001	1.23 (1.01-1.51)	0.044	1.86 (1.57-2.20)	< 0.001	1.13 (0.95-1.35)	0.172
Transfusion
No	Reference		Reference		Reference		Reference
Yes	1.98 (1.50-2.61)	< 0.001	1.00 (0.76-1.37)	0.987	1.61 (1.24-2.08)	< 0.001	0.90 (0.69-1.18)	0.455
Differentiation
I-II	Reference		Reference		Reference		Reference
III-IV	2.00 (1.71-2.34)	< 0.001	1.49 (1.27-1.76)	< 0.001	1.59 (1.40-1.81)	< 0.001	1.27 (1.11-1.45)	< 0.001
Microvascular invasion
No	Reference		Reference		Reference		Reference
Yes	2.52 (2.15-2.95)	< 0.001	1.59 (1.34-1.89)	< 0.001	2.21 (1.93-2.53)	< 0.001	1.56 (1.35-1.80)	< 0.001
Cirrhosis
No	Reference				Reference
Yes	1.02 (0.87-1.19)	0.825			1.03 (0.90-1.17)	0.667
Portal vein tumor thrombus
No	Reference		Reference		Reference		Reference
Yes	4.08 (3.28-5.07)	< 0.001	2.18 (1.73-2.74)	< 0.001	3.20 (2.60-3.95)	< 0.001	1.91 (1.53-2.38)	< 0.001
Systemic immune-inflammation index/albumin
Low	Reference		Reference		Reference		Reference
High	1.93 (1.64-2.26)	< 0.001	1.22 (1.03-1.46)	0.025	1.63 (1.42-1.87)	< 0.001	1.19 (1.03-1.38)	0.022

HR: Hazard ratio; AHR: Adjusted hazard ratio.