Whole-volume histogram analysis of spectral-computed tomography iodine maps characterizes HER2 expression in gastric cancer

Table 3 Receiver operating characteristic curve results of the iodine map histogram parameters to identify HER-2 status

Parameters	AUC (95%CI)	Sensitivity (%)	Specificity (%)	Accuracy (%)	Cutoff value	P value	Youden index
Max	0.669	76.2	53.7	58.4	40.62	0.018	0.299
Mean	0.734	81.0	61.2	65.3	19.54	0.001	0.422
SD	0.674	85.7	50.0	57.4	5.05	0.015	0.357
Variance	0.674	85.7	50.0	57.4	25.50	0.015	0.357
Entropy	0.698	85.7	50.7	57.4	3.02	0.005	0.357
1st percentile	0.691	85.7	47.5	55.4	9.18	0.007	0.332
5th percentile	0.708	71.4	60.0	62.4	11.50	0.003	0.314
10th percentile	0.713	76.2	57.5	61.4	13.50	0.003	0.337
25th percentile	0.715	76.2	58.7	62.4	15.50	0.003	0.349
50th percentile	0.736	76.2	61.2	64.4	19.50	0.001	0.374
75th percentile	0.731	81.0	55.0	60.4	27.50	0.001	0.360
90th percentile	0.733	66.7	71.2	70.3	24.57	0.001	0.379
95th percentile	0.737	71.4	67.5	68.3	26.50	0.001	0.389
99th percentile	0.740	76.2	65.0	67.3	30.50	0.001	0.412

AUC: Area under the curve.