Comparative transcriptomic analysis reveals the molecular changes of acute pancreatitis in experimental models

Figure 3 NOD-like receptor and TLR signaling pathway played a crucial role in the progression of acute pancreatitis. Significant differentially expressed genes in the NOD-like receptor and TLR signaling pathways after comparing the caerulein (CAE) group and CAE + lipopolysaccharide (LPS) group to the control (Con) group. A: Heatmap of significant differentially expressed (SDE) genes in the CAE Group compared to the Con group; B: Heatmap of SDE genes in the CAE + LPS group compared to the Con group; C: Quantitative real-time PCR (qRT-PCR) expression values of commonly significantly different genes in both groups; D: qRT-PCR expression values of specifically significantly different genes in the CAE Group compared to the Con group; E: qRT-PCR expression values of specifically significantly different genes in the CAE + LPS group compared to the Con group. n = 6 per group, ^aP < 0.01, ^bP < 0.001. CAE: Caerulein; CON: Control; LPS: Lipopolysaccharide.