Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis

Table 2 Changes in clinical indicators before and after treatment were compared between the intervention group and the nonintervention group

Characteristics	Treat		P value	Untreat		P value
	Before	After		Before	After
TBIL (μmol/L), median (IQR)	29.26 (21.025, 43.095)	27.515 (18.237, 44.22)	0.707	33.875 (26.168, 53.657)	33.3 (20.8, 57.315)	0.637
Alb (g/L), median (IQR)	32.75 (25, 39.6)	37.85 (31.635, 43.773)	0.007	30.745 (26.575, 34.825)	29.9 (26.775, 38.025)	0.625
Cr (μmol/L), median (IQR)	64.5 (54.45, 75.325)	0.85 (48.425, 69.325)	0.03	60.55 (51.35, 76.925)	61.9 (51.4, 82.125)	0.689
WBC (109/L), median (IQR)	3.89 (2.7275, 5.5775)	3.505 (2.383, 5.155)	0.321	3.88 (2.9075, 5.06)	4.115 (3, 5.493)	0.439
PLT (1012/L), median (IQR)	78 (43.25, 110.25)	71.5 (50.25, 123.25)	0.760	69 (48.25, 111.5)	69 (48.25, 103.75)	0.833
PT (s), median (IQR)	16.15 (14.6, 18.125)	15.05 (13.35, 16.6)	0.003	16.25 (14.625, 18.275)	15.95 (14, 17.75)	0.342
INR, median (IQR)	1.345 (1.216, 1.518)	1.29 (1.123, 1.408)	0.018	1.36 (1.193, 1.505)	1.315 (1.185, 1.448)	0.526
CRP, median (IQR)	4.75 (1.74, 12.8)	1.845 (0.775, 4.343)	0.005	4.995 (1.72, 9.403)	1.985 (2.035, 1.015)	0.822

TBIL: Total bilirubin; Alb: Albumin; Cr: Creatinine; WBC: White blood cell; PLT: Platelet; PT: Prothrombin time; INR: International standard ratio; CRP: C-reactive protein.