MicroRNAs: A novel signature in the metastasis of esophageal squamous cell carcinoma

Table 3 The epigenetic regulation on microRNAs in esophageal squamous cell carcinoma metastasis

miRNA (Suppressor)	Epigenetic regulation	Ref.
miR-101	~/lncMALAT1	[48,49,142]
	lncXIST/~/EZH2
	PSMA3-AS1/~/EZH2
miR-122	LINC01410/~/ PKM2	[259]
miR-129	lncNEAT1/~/CtBP2;	[28,145]
	lnc XIST/~/CCND1
miR-130a-5p	CCL18-induced lncHOTAIR/~/ZEB1	[169]
miR-133b	TTN-AS1/~/FSCN1	[102,128,129,261]
	NCK1-AS1/~/ENPEP
	lncKCNQ1OT1/~/EGFRTHAP9-AS1/~/SOX4
miR-145	lncROR/~/FSCN1	[262]
miR-140-5p	lncSNHG16/~/ZEB1	[92]
miR-186-5p	lncSNHG6/~/HIF-1α	[264]
miR-195	lncSNHG1/~/Cdc42	[265,266]
miR203	circ_0008717/~/Slug	[35,267]
	circPRMT5/~
miR206	circ_0008726/~	[20]
miR-214	FAM83A-AS1/~/CDC25B	[130,268]
	LINC00963/~/RAB14
miR-30a	OIP5AS1/~/VOPP1	[131]
miR-30d-5p	DDX11-AS1/~/SNAI1	[91]
miR-30e-5p	lncDLEU2/~/ E2F7	[126]
miR-301a	lncGAS5/~/CXCR4	[151]
miR-328	lncLOC146880/~/FSCN1	[269]
miR-33a-5p	lncDANCR/~/ZEB1	[270,271]
	lncCASC15/~/PTGS2
miR-335-5p	lncTHAP9-AS1/~/SGMS2	[124]
miR-338-3p	lncBRAF/~/IGF1R	[101,273]
	lncSNHG17/~/SOX4
miR-34a	lncMIR31HG/~/c-Met	[274]
miR-340-5p	LINC00662/~/HOXB2	[162]
miR-378a-3p	SLC2A1-AS1/~/Glut1	[132]
miR-498	lncTUG1/~/Cdc42	[46,294,278]
	AFAP1-AS1/~/VEGFA
	lncTUG1/~/XBP1
miR-508-3p	lncPCAT-1/~/ANXA10	[198]
miR-516b	lncJPX/~/VEGFA	[281]
miR-765	MAFG-AS1/~/PDX1	[135]
oncomiR
miR-18a-5p	lncPART1/~/SOX6	[61]
miR-21	LncRNA-IUR/~/PTEN	[134,282]
	HAND2-AS1/~
miR-1290	circ_0086414/~/SPARCL1circ_0001946/~/SOX6	[113,283]
miR1323	circLARP4/~/PTEN	[71]
miR-224	circ_0007624/~/CPEB3	[100]
miR-23a	circFoxo3/miR-23a	[140]
miR-125a-5p	lncHOTAIR/~/HK2	[258]
miR-124	circHIPK3/~/AKT3	[25,136]
	circ2646/~/PLP2
miR-1294	circ 0004370/~/LASP1	[260]
miR-140-3p	circNTRK2/~/NRIP1	[176,222]
	circ0087378/~/E2F3
miR-198	circLPAR3/~/C-met	[204]
miR-217	circZDHHC5/~/ZEB1	[80]
miR-27b-3p	circLONP2/~/ZEB1	[263]
miR-3612	circ_0006948/~/LASP1	[163]
miR-422a	circUBAP2/~/Rab10	[173]
miR-433-3p	circ_0023984/~/REV3L	[177]
miR-4766-5p	circPDE3B/~/LAMA1	[186]
miR-490-3p	circ_0006948/ ~/HMGA2	[192]
miR-497-5p	circ-AGFG1/~/SLC1A5	[194]
miR-595	circNRIP1/~/SEMA4D	[203]
miR-599	circHIPK3/~/c-myc	[144,205]
	circ_0030018/~/ENAH
miR-615-5p	circOGDH/~/PDX1	[139]
miR-622	circ_0001273/~/SLC1A5	[138]
miR-670-3p	circABCB10/~	[139]
miR-874-3p	circ0000977/~	[272]
miR-126	DNMT1/~/ADAM9	[141]
miR-137	CTCF/(DNA methylation) /~/EZH2+PXN	[174]
miR-107	circSFMBT2/~/SLC1A5	[275,276]
	LINC00152/~/Rab10
miR-149-5p	lnc GACAT3/~/FOXM1	[10,277]
	circ_0000654/~/IL-6
miR-326	LINC01711/~/FSCN1	[154,279]
	circATIC/~/ID1
miR-377	LncNEAT1/~/E2F3	[171,280]
	circ_0072088/~/VEGF
miR-493	LINC00324/~/MAPK1	[145,146]
	circFIG4/~/E2F3
miR-124-3p	lncZFAS1/~/STAT3	[31,156]
	DNMT1/~/BCAT1 ~/EZH2/H3K27me3
miR-10b-3p	DNA methylation; Hypoxia	[56,57]
miR-320b	DGCR8+METTL3- N6 -methyladenosine (m6A)/~	[53]
miR-483-5p	Igf2 methylationgene promoter/Igf2/~/ARHGDIA	[66]
miR-602	CpG hypomethylation/~	[54]
miR-515-3p	Promoter hypomethylation	[12]