Adenosine 2A receptor contributes to the facilitation of post-infectious irritable bowel syndrome by γδ T cells via the PKA/CREB/NF-κB signaling pathway

Figure 5 Adenosine 2A receptor mediated signaling pathway that could regulate the function of γδ T cells. A: The PKA/p-PKA, CREB/p-CREB, NF-κB/p-NF-κB protein levels in γδ T cells of post-infectious irritable bowel syndrome (PI-IBS) mice. β-Actin is used as the loading control; B: The relative PKA level in γδ T cells from mice with PI-IBS; C: The relative CREB level in γδ T cells from PI-IBS mice; D: The relative NF-κB level in γδ T cells from mice with PI-IBS. The results from three times of independently repeated experiments were gathered and analyzed. PI-IBS: Post-infectious irritable bowel syndrome. ^aP < 0.05, ^bP < 0.01, ^eP < 0.001 vs the γδ T cell group.