Role of noncoding RNAs in liver fibrosis

doi:10.3748/wjg.v29.i9.1446

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Mar 7, 2023; 29(9): 1446-1459
Published online Mar 7, 2023. doi: 10.3748/wjg.v29.i9.1446

Table 2 Noncoding RNAs for the potential treatment of liver fibrosis

ncRNAs	Target genes	Signaling pathways	Ref.
miR-29a	PI3KP85α	PI3K/AKT	[79]
	Fstl	TGF-β/Smad2, JNK	[21]
miR-223	NLRP3 inflammasome	NOD signaling pathway	[81]
	GLI2, PDGFRα/β	Hedgehog, PDGF	[82]
hB-MSCs-derived exo-miR-618	Smad4	TGF-β/Smad2	[87]
3DhESCs-derived exo-miR-6766-3p	TGFβRII	TGF-β/Smad	[89]
hT-MSCs-derived exo-miR-486	Smo	Hedgehog/GlI2	[88]
NK cells-derived exo-miR-223	ATG7	Autophagy pathway	[85]
KCs-derived exo-miR-690	NADK	-	[84]
lncRNA SNHG	miR-15a, MURF1	UVRAG/ATG5/Wnt5a	[93]
lncRNA BIHAA1	miR-667-5p	-	[92]
MSCs-derived exo-circDIDO1	miR-141-3p	PTEN/AKT	[73]
MSCs-derived exo-circCDK13	miR-17-5p, KAT2B	PI3K/AKT, NF-κB	[94]

ncRNAs: Noncoding RNAs; PI3K: Phosphatidylinositol 3-kinase; AKT: Serine/threonine kinase 1; Fstl: Follistatin-like 1; TGF-β: Transforming growth factor-β; JNK: c-Jun N-terminal kinase; NLRP3: NOD-like receptor family, pyrin domain containing 3; Smo: Smoothened; GLI2: Gliotactin family zinc finger 2; PDGFR: Platelet-derived growth factor receptor; MSC: Mesenchymal stem cell; hB-MSC: Human bone MSC; hT-MSC: Human tonsil-derived MSC; 3DhESC: 3D-cultured human embryonic stem cells; TGF-βRII: TGF-β type II receptor; ATG: Autophagy-related gene; KCs: Kupffer cells; NADK: NAD kinase; SNHG: Small nucleolar RNA host gene; SMURF1: Smad ubiquitin regulatory factor 1; UVRAG: UV radiation resistance associated gene; DIDO1: Death inducer-obliterator 1; PTEN: Phosphatase and tensin homology deleted on chromosome ten; CDK13: Cyclin dependent kinase 13; KAT2B: K (lysine) acetyltransferase 2B.

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Citation: Li QY, Gong T, Huang YK, Kang L, Warner CA, Xie H, Chen LM, Duan XQ. Role of noncoding RNAs in liver fibrosis. World J Gastroenterol 2023; 29(9): 1446-1459
URL: https://www.wjgnet.com/1007-9327/full/v29/i9/1446.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i9.1446

Li QY, Gong T, Huang YK, Kang L, Warner CA, Xie H, Chen LM, Duan XQ. Role of noncoding RNAs in liver fibrosis. World J Gastroenterol 2023; 29(9): 1446-1459 [PMID: 36998425 DOI: 10.3748/wjg.v29.i9.1446]

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