Retrospective Study
Copyright ©The Author(s) 2023.
World J Gastroenterol. Nov 21, 2023; 29(43): 5804-5817
Published online Nov 21, 2023. doi: 10.3748/wjg.v29.i43.5804
Table 1 Demographic and clinical characteristics of patients
Variable

Overall (n = 371)
No HCC recurrence (n = 152)
HCC recurrence (n = 219)
P value
Training set (n = 296)
Test set (n = 75)
P value
Liver cirrhosis, n (%)No85 (22.911)28 (18.421)57 (26.027)0.08685 (22.911)69 (23.311)0.716
Yes286 (77.089)124 (81.579)162 (73.973)227 (76.689)59 (78.667)
Tumor size, n (%), cm≤ 242 (11.321)16 (10.526)26 (11.872)0.02729 (9.797)13 (17.333)0.308
2-5168 (45.283)78 (51.316)90 (41.096)137 (46.284)31 (41.333)
5-10109 (29.380)46 (30.263)63 (28.767)87 (29.392)22 (29.333)
≥ 1052 (14.016)12 (7.895)40 (18.265)43 (14.527)9 (12.000)
Tumor number, n (%)1285 (76.819)128 (84.211)157 (71.689)0.005229 (77.365)56 (74.667)0.621
≥ 286 (23.181)24 (15.789)62 (28.311)67 (22.635)19 (25.333)
Homogeneous tumor enhancement, n (%)No297 (80.054)119 (78.289)178 (81.279)0.479238 (80.405)59 (78.667)0.736
Yes74 (19.946)33 (21.711)41 (18.721)58 (19.595)16 (21.333)
Intratumoral necrosis, n (%)No142 (38.275)69 (45.395)73 (33.333)0.019113 (38.176)29 (38.667)0.938
Yes229 (61.725)83 (54.605)146 (66.667)183 (61.824)46 (61.333)
Tumor envelope intactness, n (%)No145 (39.084)60 (39.474)85 (38.813)0.898117 (39.527)28 (37.333)0.728
Yes226 (60.916)92 (60.526)134 (61.187)179 (60.473)47 (62.667)
Regular tumor margin, n (%)No176 (47.439)73 (48.026)103 (47.032)0.850139 (46.959)37 (49.333)0.713
Yes195 (52.561)79 (51.974)116 (52.968)157 (53.041)38 (50.667)
Intratumoral arteries, n (%)No174 (46.900)89 (58.553)85 (38.813)< 0.001135 (45.608)39 (52.000)0.322
Yes197 (53.100)63 (41.447)134 (61.187)161 (54.392)36 (48.000)
Adjacency to major vessels, n (%)No216 (58.221)93 (61.184)123 (56.164)0.335171 (57.770)45 (60.000)0.727
Yes155 (41.779)59 (38.816)96 (43.836)125 (42.230)30 (40.000)
Ascitic fluid, n (%)No262 (70.620)106 (69.737)156 (71.233)0.756207 (69.932)55 (73.333)0.564
Yes109 (29.380)46 (30.263)63 (28.767)89 (30.068)20 (26.667)
Age, n (%), yr< 60227 (61.186)85 (55.921)142 (64.840)0.083187 (63.176)40 (53.333)0.118
≥ 60144 (38.814)67 (44.079)77 (35.160)109 (36.824)35 (46.667)
Gender, n (%)Male280 (75.472)118 (77.632)162 (73.973)0.421221 (74.662)59 (78.667)0.472
Female91 (24.528)34 (22.368)57 (26.027)75 (25.338)16 (21.333)
HBsAg, n (%)Negative101 (27.224)41 (26.974)60 (27.397)0.92876 (25.676)25 (33.333)0.183
Positive270 (72.776)111 (73.026)159 (72.603)220 (74.324)50 (66.667)
HBeAg, n (%)Negative289 (77.898)123 (80.921)166 (75.799)0.242229 (77.365)60 (80.000)0.623
Positive82 (22.102)29 (19.079)53 (24.201)67 (22.635)15 (20.000)
ALBI, n (%), grade167 (18.059)26 (17.105)41 (18.721)0.90754 (18.243)13 (17.333)0.710
2288 (77.628)119 (78.289)169 (77.169)228 (77.027)60 (80.000)
316 (4.313)7 (4.605)9 (4.110)14 (4.730)2 (2.667)
MLR, n (%)< 0.285171 (46.092)75 (49.342)96 (43.836)0.295140 (47.297)31 (41.333)0.355
≥ 0.285200 (53.908)77 (50.658)123 (56.164)156 (52.703)44 (58.667)
GLR, n (%)< 32.16190 (51.213)92 (60.526)98 (44.749)0.003152 (51.351)38 (50.667)0.916
≥ 32.16181 (48.787)60 (39.474)121 (55.251)144 (48.649)37 (49.333)
PLR, n (%)< 138.18300 (80.863)132 (86.842)168 (76.712)0.015241 (81.419)59 (78.667)0.588
≥ 138.1871 (19.137)20 (13.158)51 (23.288)55 (18.581)16 (21.333)
ALP, n (%)< 80.29280 (75.472)121 (79.605)159 (72.603)0.123222 (75.000)58 (77.333)0.675
≥ 80.2991 (24.528)31 (20.395)60 (27.397)74 (25.000)17 (22.667)
LMR, n (%)< 5.3382 (22.102)28 (18.421)54 (24.658)0.15567 (22.635)15 (20.000)0.623
≥ 5.33289 (77.898)124 (81.579)165 (75.342)229 (77.365)60 (80.000)
FAR, n (%)< 0.07220 (59.299)96 (63.158)124 (56.621)0.208174 (58.784)46 (61.333)0.688
≥ 0.07151 (40.701)56 (36.842)95 (43.379)122 (41.216)29 (38.667)
SII, n (%)< 312.71198 (53.369)93 (61.184)105 (47.945)0.012157 (53.041)41 (54.667)0.801
≥ 312.71173 (46.631)59 (38.816)114 (52.055)139 (46.959)34 (45.333)
AFP, n (%), ng/mL< 20171 (46.092)81 (53.289)90 (41.096)0.012138 (46.622)33 (44.000)0.857
20-40086 (23.181)37 (24.342)49 (22.374)69 (23.311)17 (22.667)
≥ 400114 (30.728)34 (22.368)80 (36.530)89 (30.068)25 (33.333)
PLT, median (IQR), 109/L168.000 (113.000, 209.000)154.000 (112.000, 200.000)171.000 (118.000, 216.000)0.110165.000 (111.000, 208.000)178.000 (133.000, 220.000)-1.451
Blood glucose, median (IQR), mmol/L4.720 (4.340, 5.310)4.840 (4.390, 5.660)4.660 (4.300, 5.170)0.0094.710 (4.350, 5.310)4.770 (4.300, 5.310)-0.066