Clinical significance of programmed cell death-ligand expression in small bowel adenocarcinoma is determined by the tumor microenvironment

Table 4 Mutual relationship of programmed cell death-ligand 1, programmed cell death-ligand 2, CD8 and FoxP3 (n = 50)

	I-PD-L1	PD-L1 CPS ≥ 10	T-PD-L2	I-PD-L2	PD-L2 CPS ≥ 10	FoxP3	CD8	FoxP3/CD8
T-PD-L1	0.002	< 0.001	0.042	0.003	0.001	NS	0.007	NS
I-PD-L1		< 0.001	NS	0.019	0.002	0.005	0.047	NS
PD-L1 CPS ≥ 10			NS	0.010	0.004	0.048	0.011	NS
T-PD-L2				< 0.001	< 0.001	NS	NS	NS
I-PD-L2					< 0.001	NS	0.002	0.0451
PD-L2 CPS ≥ 10						NS	0.004	NS
FoxP3							NS	0.002
CD8								< 0.0011

¹An inverse relationship.

PD-L1: Programmed cell death-ligand 1; PD-L2: Programmed cell death-ligand 2; NS: Not significant.