Diagnostic and economic value of carcinoembryonic antigen, carbohydrate antigen 19-9, and carbohydrate antigen 72-4 in gastrointestinal cancers

Table 10 The best single biomarker and the best combination of biomarkers for gastric cancer, colorectal cancer and gastrointestinal cancers

	Best combination		Best single biomarker		P value
	Biomarkers	AUC	Biomarker	AUC
Gastric cancer	CEA + CA19-9 + CA72-4	0.653	CEA	0.625	0.067
Colorectal cancer	CEA + CA19-9	0.761	CEA	0.736	< 0.001
Gastrointestinal cancers	CEA + CA19-9	0.727	CEA	0.705	< 0.001

The bold font indicates that the P value was less than 0.05 in Delong’s test. AUC: Area under the curve; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; CA72-4: Carbohydrate antigen 72-4.