Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells

Figure 1 Pathological changes in mouse liver tissues after rAAV-Angiotensin-converting enzyme 2 treatment (magnification × 100). A: Effect of rAAV-ACE2 treatment on liver fibrosis in mice was assessed by Hematoxylin and eosin staining; B: Effect of rAAV-ACE2 treatment on liver fibrosis in mice was assessed by Masson trichrome staining; C: Effect of rAAV-ACE2 treatment on liver fibrosis in mice was assessed by Sirius red staining; D: The quantity of collagen production in each group was analyzed using Image-Pro Plus 6.0. ^aP < 0.01 vs Control; ^bP < 0.05 vs CCl₄; ^cP < 0.05 vs rAAV-ACE2 + CCl₄. Rapa: Rapamycin; ACE2: Angiotensin-converting enzyme 2.