Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies in the targeted therapy era

doi:10.3748/wjg.v29.i33.4942

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2023; 29(33): 4942-4961
Published online Sep 7, 2023. doi: 10.3748/wjg.v29.i33.4942

Table 6 Recommendations for management strategy of hepatitis B virus-infected cancer patients receiving novel agents for hematological malignancies

Therapy	Chronic HBV infection	Past resolved HBV infection
CAR-T (e.g., axicabtagene ciloleucel, tisagenlecleucel, and lisocabtagene maraleucel)	Antiviral prophylaxis	Antiviral prophylaxis
Bispecific antibodies (e.g., glofitamab, mosunetuzumab)	Antiviral prophylaxis	Antiviral prophylaxis
BTK inhibitors (e.g., ibrutinib, acalabrutinib, zanubrutinib)	Antiviral prophylaxis	Antiviral prophylaxis or monitoring and pre-emptive therapy¹
BCL-2 inhibitors (venetoclax)	Antiviral prophylaxis	Antiviral prophylaxis or monitoring and pre-emptive therapy¹
Anti-CD19 monoclonal antibody (blinatumumab)	Antiviral prophylaxis	Antiviral prophylaxis
Anti-CD22 monoclonal antibody (inotuzumab)	Antiviral prophylaxis	Antiviral prophylaxis
Anti-CD79 monoclonal antibody (polatuzumab)	Antiviral prophylaxis	Antiviral prophylaxis
Anti-CD38 monoclonal antibody (daratumumab)	Antiviral prophylaxis	Antiviral prophylaxis

¹Pre-emptive therapy is monitoring of serum hepatitis B virus DNA every 1-3 mo during and after immunosuppression, and starting antiviral therapy with entecavir or tenofovir in the case of detectable hepatitis B virus DNA levels.

HBV: Hepatitis B virus; CAR: Chimeric antigen receptor; BTK: Bruton tyrosine kinase; BCL: B-cell lymphoma.

Citation: Mak JWY, Law AWH, Law KWT, Ho R, Cheung CKM, Law MF. Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies in the targeted therapy era. World J Gastroenterol 2023; 29(33): 4942-4961
URL: https://www.wjgnet.com/1007-9327/full/v29/i33/4942.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i33.4942