Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies in the targeted therapy era

Table 4 Drug classes and corresponding risk of hepatitis B virus reactivation[6]

Drug class	Drug or dose	Risk of HBV reactivation
		For HBsAg-positive patients	For HBsAg-negative/anti-HBc-positive patients
Anti-CD20 monoclonal antibodies	Rituximab, obinutuzumab, ofatumumab	High (30%-60%)	High (> 10%)
Anthracycline chemotherapy	Doxorubicin, daunorubicin, epirubicin	High (15%-30%)	High (> 10%)
Steroids	Moderate/high dose ≥ 4 wk	High (> 10%)	Moderate (1%-10%)
	Low dose ≥ 4 wk	Moderate (1%-10%)	Low (< 1%)
	Low dose ≤ 1 wk	Low (< 1%)	Low (< 1%)
Tyrosine kinase inhibitors	Imatinib, nilotinib, dasatinib	High to moderate	Low (< 1%)
Immune checkpoint inhibitors	Nivolumab, pembrolizumab	High (> 10%)	Uncertain
Proteasome inhibitor	Bortezomib	Moderate (1%-10%)	Moderate (1%-10%)

HBV: Hepatitis B virus; HBsAg: Hepatitis B surface antigen; anti-HBc: Antibody to hepatitis B core.