Exploring the regulatory mechanism of tRNA-derived fragments 36 in acute pancreatitis based on small RNA sequencing and experiments

Figure 6 A schematic of a putative mechanism of tRNA-derived fragments 36 in the progression of acute pancreatitis. In this model, tRNA-derived fragments 36 might recruit insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) to the p53 mRNA m6A modification site by binding to IGF2BP3 to enhance p53 mRNA stability and promote the ferroptosis of pancreatic follicle cells. tRF-36: tRNA-derived fragments 36; IGF2BP3: Insulin-like growth factor 2 mRNA binding protein 3.