Meta-Analysis
Copyright ©The Author(s) 2023.
World J Gastroenterol. Aug 14, 2023; 29(30): 4685-4700
Published online Aug 14, 2023. doi: 10.3748/wjg.v29.i30.4685
Table 2 Subgroup analysis of the diagnostic value of conventional endoscopic ultrasound for lymph node metastasis in upper gastrointestinal neoplasia
Subgroup
Studies
Sensitivity (95%CI)
Specificity (95%CI)
PLR (95%CI)
NLR (95%CI)
DS (95%CI)
DOR (95%CI)
AUC (95%CI)
All studies220.62 (0.50-0.73)0.80 (0.73-0.86)3.15 (2.46-4.03)0.47 (0.36-0.61)1.90 (1.51-2.29)6.67 (4.52-9.84)0.80 (0.76-0.83)
Tumor typeEsophageal cancer120.64 (0.51-0.76)0.81 (0.70-0.88)3.33 (2.27-4.87)0.44 (0.33-0.59)2.02 (1.53-2.50)7.52 (4.64-12.18)0.79 (0.75-0.83)
Gastric cancer100.59 (0.38-0.76)0.80 (0.71-0.87)2.95 (2.09-4.17)0.52 (0.34-0.79)1.74 (1.09-2.40)5.71 (2.96-10.99)0.79 (0.75-0.82)
Study areaEastern country100.63 (0.42-0.80)0.84 (0.72-0.91)3.83 (2.46-5.95)0.44 (0.28-0.71)2.15 (1.48-2.83)8.62 (4.38-16.94)0.82 (0.79-0.85)
Western country120.61 (0.48-0.73)0.76 (0.69-0.82)2.57 (2.13-3.11)0.51 (0.38-0.67)1.62 (1.26-1.99)5.07 (3.53-7.30)0.77 (0.73-0.80)
Publication year2010-2018160.60 (0.44-0.74)0.82 (0.75-0.88)3.36 (2.58-4.38)0.48 (0.35-0.68)1.94 (1.47-2.41)6.93 (4.34-11.08)0.81 (0.77-0.84)
2000-200960.70 (0.56-0.81)0.75 (0.56-0.88)2.79 (1.50-5.18)0.41 (0.27-0.62)1.93 (1.01-2.85)6.87 (2.74-17.22)0.78 (0.74-0.81)
Sample size≥ 100 cases90.60 (0.46-0.73)0.78 (0.67-0.87)2.79 (2.14-3.65)0.51 (0.40-0.65)1.71 (1.45-1.97)5.52 (4.24-7.18)0.76 (0.72-0.80)
< 100 cases130.65 (0.61-0.90)0.83 (0.72-0.89)3.80 (2.45-5.89)0.42 (0.26-0.69)2.20 (1.42-2.99)9.04 (4.13-19.81)0.83 (0.80-0.86)
EUS diagnostic criteria1Criteria 1100.62 (0.50-0.73)0.79 (0.71-0.86)3.04 (2.38-3.88)0.47 (0.37-0.60)1.86 (1.58-2.14)6.43 (4.84-8.54)0.78 (0.74-0.82)
Criteria 2120.61 (0.41-0.79)0.81 (0.70-0.88)3.17 (2.19-4.60)0.48 (0.30-0.75)1.89 (1.22-2.57)6.63 (3.37-13.05)0.80 (0.76-0.83)
1Criteria 1 (hypoechoic, round, well-defined margin, diameter ≥ 10mm), Criteria 2 (others).
PLR: Positive likelihood ratio; NLR: Negative likelihood ratio; DS: Diagnostic score; DOR: Diagnostic odds ratio; AUC: Area under the curve.