Peroxisome proliferator-activated receptors as targets to treat metabolic diseases: Focus on the adipose tissue, liver, and pancreas

Figure 3 Beneficial effects of Peroxisome proliferator-activated receptor agonist on islet remodelling. Diet-induced obese mice exhibit enlarged pancreatic islets, with are prone to exhaustion in the long run due to glucolipotoxicity. Peroxisome proliferator-activated receptor α (PPARα) and partial PPARγ activation are promising targets to counter glucolipotoxicity, yielding islet preservation. Made with Biorender (www.biorender.com). PPARs: Peroxisome proliferator-activated receptors; GSIS: Glucose-stimulated insulin secretion; ER: Endoplasmic reticulum. Created by BioRender.