Prediction of lymph node metastasis in early gastric signet-ring cell carcinoma: A real-world retrospective cohort study

Table 8 Logistic regression analysis of the risk factors of lymph node metastasis in pure and mixed signet-ring cell carcinoma

	LNM				Univariate		Multivariate analysis
	Present		Absent		P value		OR, 95%CI, P value
	Pure	Mixed	Pure	Mixed	Pure	Mixed	Pure	Mixed
Total	8	54	87	100
Age					1	1
≤ 65	7	33	58	63
> 65	1	21	29	37
Gender					1	0.377
Male	3	29	39	62
Female	5	25	48	38
Location					0.706	0.412
Cardia	0	2	4	5
Fundus	0	1	2	2
Body	1	9	12	21
Antrum	5	28	46	50
Angle	2	14	23	22
Macroscopic type					0.788	0.314
Protruded (0-I)	0	0	1	2
Elevated (0-IIa)	0	1	5	5
Flat (0-IIb)	3	10	20	19
Depressed (0-IIc)	4	42	61	71
Excavated (0-III)	1	1	0	3
Tumor size (cm)					0.014	0.751
≤ 2	4	26	56	53			1
> 2	4	28	31	47			5.422 (1.095-26.856), 0.038
Ulceration					1	0.189
UL (-)	6	31	69	69
UL (+)	2	23	18	31
Depth of invasion					0.045	0.004
M	3	17	70	59				1
SM	5	37	17	41				2.395 (0.891-4.998), 0.054
LVI					-	< 0.001
Absence	8	38	87	98				1
Presence	0	16	0	2				16.173 (4.085-76.619), 0.001
Perineural invasion					1	0.376
Absence	8	50	86	98
Presence	0	4	1	2
Mixed component						0.458
Differentiated	-	1	-	7
Undifferentiated	-	30	-	58
Mixed	-	23	-	35

M: Mucosal; SM: Submucosal; LNM: Lymph node metastasis; LVI: Lymphovascular invasion; UL (-): Ulcer or ulcer scar is absent; UL (+): Ulcer or ulcer scar is present.