Prediction of lymph node metastasis in early gastric signet-ring cell carcinoma: A real-world retrospective cohort study

Table 6 Logistic regression analysis of the risk factors of lymph node metastasis in signet-ring cell carcinoma

	LNM		Univariate	Multivariate analysis
	Present	Absent	P value	OR	95%CI	P value
Total	62	187
Age			0.617
≤ 65	41	120
> 65	21	67
Gender			0.639
Male	32	101
Female	30	86
Location			0.544
Cardia	2	9
Fundus	1	4
Body	10	33
Antrum	33	96
Angle	16	45
Macroscopic type			0.209
Protruded (0-I)	0	3
Elevated (0-IIa)	1	10
Flat (0-IIb)	13	39
Depressed (0-IIc)	46	132
Excavated (0-III)	2	3
Tumor size (cm)			0.351
≤ 2	30	109
> 2	32	78
Ulceration			0.06
UL (-)	37	128
UL (+)	25	46
Depth of invasion			< 0.001
M	20	129		1
SM	42	58		2.615	1.282-5.334	0.008
LVI			< 0.001
Absence	46	185		1
Presence	16	2		14.903	3.143-70.680	0.001
Perineural invasion			0.146
Absence	58	184
Presence	4	3
Histological type			< 0.001
Pure SRCC	8	87		1
Mixed SRCC	54	100		1.982	0.923-4.237	0.043

SRCC: Signet-ring cell carcinoma; M: Mucosal; SM: Submucosal; LNM: Lymph node metastasis; LVI: Lymphovascular invasion; UL (-): Ulcer or ulcer scar is absent; UL (+): Ulcer or ulcer scar is present.