Prediction of lymph node metastasis in early gastric signet-ring cell carcinoma: A real-world retrospective cohort study

Table 2 Logistic regression analysis of the risk factors of lymph node metastasis in early gastric cancer

	LNM		Univariate	Multivariate analysis
	Present	Absent	P value	OR	95%CI	P value
Total	278	1644
Age			0.015
≤ 65	135	660
> 65	143	984
Gender			< 0.001
Male	160	1211		1
Female	118	433		1.912	1.392-2.626	< 0.001
Location			0.001
Cardia	17	229
Fundus	9	139
Body	45	294
Antrum	141	629
Angle	66	353
Macroscopic type			0.008
Protruded (0-I)	9	21
Elevated (0-IIa)	16	123
Flat (0-IIb)	37	368
Depressed (0-IIc)	201	1053
Excavated (0-III)	15	79
Tumor size (cm)			< 0.001
≤ 2	134	1129		1
> 2	144	515		1.875	1.260-2.417	0.001
Ulceration			< 0.001
UL (-)	134	1087		1
UL (+)	144	557		1.695	1.246-2.306	0.001
Depth of invasion			< 0.001
M	54	903		1
SM	224	741		3.34	2.156-5.174	< 0.001
LVI			< 0.001
Absence	199	1587		1
Presence	79	57		6.682	4.358-10.245	< 0.001
Perineural invasion			< 0.001
Absence	262	1638
Presence	16	6
Histological type
Pure SRCC	8	87	< 0.001	1		< 0.001
NSRC	216	1457		2.619	1.454-3.598	0.894
Mixed SRCC	54	100		4.595	2.654-6.954	< 0.001

SRCC: Signet-ring cell carcinoma; NSRC: Non-signet ring cell carcinoma; M: Mucosal; SM: Submucosal; LVI: Lymphovascular invasion; LNM: Lymph node metastasis; UL (-): Ulcer or ulcer scar is absent; UL (+): Ulcer or ulcer scar is present.