Novel multi-parametric diagnosis of non-alcoholic fatty liver disease using ultrasonography, body mass index, and Fib-4 index

doi:10.3748/wjg.v29.i23.3703

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2023; 29(23): 3703-3714
Published online Jun 21, 2023. doi: 10.3748/wjg.v29.i23.3703

Table 2 Comparison of the two groups classified by area of non-alcoholic steatohepatitis pentagon

	Large pentagon group (n = 64)	Small pentagon group (n = 43)	P value
M/F	33/31	28/15	0.165
Age (yr)	60.8 ± 15.2	46.4 ± 13.2	< 0.0001
Metabolic diseases
Diabetes mellitus (yes/no)	18/46	6/37	0.0849
Dyslipidemia (yes/no)	27/37	8/35	0.0108
Hypertension (yes/no)	29/35	7/36	0.0183
AST (U/L)	52.6 ± 44.2	40.3 ± 24.4	0.0521
ALT (U/L)	61.1 ± 45.2	83.0 ± 71.6	0.1699
GGT (U/L)	97.3 ± 123.2	102.9 ± 162.0	0.7238
T-B (mg/dL)	1.01 ± 0.6	0.77 ± 0.3	0.0044
Alb (mg/dL)	4.5 ± 0.4	4.6 ± 0.4	0.2843
eGFR (mL/min)	71.8 ± 16.4	74.7 ± 12.1	0.1639
HbA1c (%)	6.5 ± 1.1	6.3 ± 1.2	0.2847
T-chol (mg/dL)	188.5 ± 59.4	221.3 ± 33.8	0.008
TG (mg/dL)	172.9 ± 126.5	189.9 ± 108.8	0.1278
WBC (10³/μL)	6225.0 ± 1586.9	7463.9 ± 2050.9	0.008
Hb (g/dL)	14.7 ± 1.3	14.7 ± 1.5	0.6836
Plts (10⁴/μL)	21.0 ± 6.5	28.8 ± 6.6	< 0.0001
SWS (m/s)	1.78 ± 0.36	1.39 ± 0.14	< 0.0001
DS [(m/s)/kHz]	13.3 ± 3.7	10.8 ± 2.0	< 0.0001
ATI value [(dB/cm)/MHz]	0.78 ± 0.13	0.74 ± 0.13	0.1047
Fib-4 index	2.2 ± 2.3	0.7 ± 0.4	< 0.0001
BMI (kg/m²)	27.8 ± 4.4	25.6 ± 3.2	0.0249
NASH/NAFL	22/42	3/40	0.0042

M: Male; F: Female; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: γ-glutamyltransferase; T-chol: Total cholesterol; TG: Triglycerides; WBC: White blood cells; Hb: Hemoglobin; Plts: Platelets; SWS: Shear wave speed; DS: Dispersion slope; ATI value: Attenuation imaging value; BMI: Body mass index; Alb: Albumin; eGFR: Estimated glomerular filtration rate; NASH: Non-alcoholic steatohepatitis; NAFL: Non-alcoholic fatty liver.

Citation: Funada K, Kusano Y, Gyotoku Y, Shirahashi R, Suda T, Tamano M. Novel multi-parametric diagnosis of non-alcoholic fatty liver disease using ultrasonography, body mass index, and Fib-4 index. World J Gastroenterol 2023; 29(23): 3703-3714
URL: https://www.wjgnet.com/1007-9327/full/v29/i23/3703.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i23.3703