Lymphocyte-to-white blood cell ratio is associated with outcome in patients with hepatitis B virus-related acute-on-chronic liver failure

Table 2 Univariate and multivariate Cox regression analyses in hepatitis B virus-acute on chronic liver failure patients (n = 330)

	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age	1.021 (1.007-1.035)	0.002	1.015 (1.001-1.030)	0.037
Male sex	1.202 (0.747-1.932)	0.448
PLT (109/L)	0.997 (0.994-0.999)	0.046
PT (s)	1.020 (1.011-1.030)	< 0.001	1.028 (1.015-1.042)	< 0.001
INR	1.042 (0.993-1.094)	0.093
Hemoglobin (g/L)	0.993 (0.987-0.999)	0.027
Bilirubin (μmol/L)	1.001 (1.000-1.003)	0.025	1.001 (1.000-1.003)	0.041
Albumin (g/L)	0.968 (0.933-1.005)	0.091
Creatinine (μmol/L)	1.001 (1.000-1.001)	0.179
BUN (mmol/L)	1.036 (1.014-1.058)	0.001
Serum Na (mmol/L)	1.001 (0.999-1.003)	0.249
LWR	0.011 (0.001-0.088)	< 0.001	0.052 (0.005-0.535)	0.013

In univariate analysis, P < 0.1 were subjected to multivariate analysis and was indicated in bold; in multivariate analysis, P < 0.05 was considered significant and was indicated in bold. CI: Confidence interval; HR: Hazard ratio; PLT: Platelet; PT: Prothrombin time; INR: International normalized ratio; BUN: Blood urea nitrogen; LWR: Lymphocyte-to-white blood cell ratio.