Plasma exosomal hsa_circ_0079439 as a novel biomarker for early detection of gastric cancer

Figure 6 Diagnostic value and expression levels of exosomal hsa_circ_0079439, carcinoembryonic antigen, carbohydrate antigen 19-9, carbohydrate antigen 72-4, alpha-fetoprotein, and carbohydrate antigen 125 among healthy donors, early gastric cancer patients, and advanced gastric cancer patients. A: Absolutely quantitative detection of exosomal hsa_circ_0079439 copy number in plasma from early gastric cancer (EGC) patients (n = 177), advanced GC (AGC) patients (n = 63), and healthy donors (HDs) (n = 63) by droplet digital polymerase chain reaction; B-F: Expression levels of standard serum biomarkers in EGC patients, AGC patients, and HDs, including carcinoembryonic antigen (CEA) (B), carbohydrate antigen (CA)19-9 (C), CA72-4 (D), alpha-fetoprotein (E), and CA125 (F); G: Receiver operating characteristic (ROC) curves of hsa_circ_0079439, CEA, CA19-9, CA72-4, alpha-fetoprotein, and CA125 in distinguish EGC patients from HDs; H: ROC curves of hsa_circ_0079439, CEA, CA19-9, CA72-4, alpha-fetoprotein, and CA125 in distinguish AGC patients from HDs. All the results are shown as the mean (SD). ^aP < 0.05, ^bP < 0.0001, NS: Not significant. HD: Healthy donor; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; CA72-4: Carbohydrate antigen 72-4; CA 125: Carbohydrate antigen 125; AFP: Alpha-fetoprotein; EGC: Early gastric cancer; AGC: Advanced gastric cancer.