Difference and clinical value of metabolites in plasma and feces of patients with alcohol-related liver cirrhosis

doi:10.3748/wjg.v29.i22.3534

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 14, 2023; 29(22): 3534-3547
Published online Jun 14, 2023. doi: 10.3748/wjg.v29.i22.3534

Table 3 Differential metabolites in plasma and feces

Metabolites	Metabolic pathway	Plasma (ALC/HC)	Feces (ALC/HC)
Cholic acid	Bile acid biosynthesis	↑	NS
Glycocholic acid		↑	NS
Taurocholic acid		↑	NS
Deoxycholic acid		↑	↓
Glycine	Alanine metabolism	NS	↑
	Arginine and proline metabolism
	Glutathione metabolism
	Bile acid biosynthesis
Taurine	Taurine and hypotaurine metabolism	↑	NS
Taurine	Bile acid biosynthesis	↑	NS
Betaine	Glycine and serine metabolism	↓	↓
Betaine	Methionine metabolism	↓	↓
L-Methionine	Glycine and serine metabolism	↑	NS
L-Methionine	Methionine metabolism	↑	NS
L-Threonine	Glycine and serine metabolism	↑	↑
Choline	Methionine metabolism	↑	↑
Sarcosine	Methionine metabolism	↓	NS
L-Phenylalanine	Phenylalanine and tyrosine metabolism	↑	↑
L-Tyrosine	Phenylalanine and tyrosine metabolism	↑	↑
Formylanthranilic acid	Tryptophan metabolism	↓	NS
L-Valine	Valine, leucine and isoleucine degradation	↓	↑

Compared to healthy controls, variation trend of bile acid and amino acid in plasma or feces of patients with alcohol-related liver cirrhosis. NS: Not significant; ALC: Alcohol-related liver cirrhosis; HC: Healthy control.

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Citation: Xu YF, Hao YX, Ma L, Zhang MH, Niu XX, Li Y, Zhang YY, Liu TT, Han M, Yuan XX, Wan G, Xing HC. Difference and clinical value of metabolites in plasma and feces of patients with alcohol-related liver cirrhosis. World J Gastroenterol 2023; 29(22): 3534-3547
URL: https://www.wjgnet.com/1007-9327/full/v29/i22/3534.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i22.3534

Xu YF, Hao YX, Ma L, Zhang MH, Niu XX, Li Y, Zhang YY, Liu TT, Han M, Yuan XX, Wan G, Xing HC. Difference and clinical value of metabolites in plasma and feces of patients with alcohol-related liver cirrhosis. World J Gastroenterol 2023; 29(22): 3534-3547 [PMID: 37389241 DOI: 10.3748/wjg.v29.i22.3534]

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