SARS-CoV-2 induced liver injury: Incidence, risk factors, impact on COVID-19 severity and prognosis in different population groups

Table 3 Serum parameters alone or in combination associated with specific outcomes

Parameters	Associated conditions
ALT	CSS inflammatory markers
Elevated serum IL-2R, IL-6, TNF-α	LI
IL-6, ferritin, CRP, ESR, Procalcitonin, hypoalbuminemia, low PLTs, low CD4+ T-cells and B-lymphocytes	Non-favorable course of LI
Simultaneous increase in IL-6 + ferritin + ALT + hypoalbuminaemia	Significant LI
On admission increased inflammatory markers + AST + GGT + LDH + lymphopenia+eosinopenia	More Severe clinical course
Lymphopenia, Thrombocytopenia	Disease severity
Thrombocytopenia	Consumptive coagulopathy
Low Hb	Controversial data

ALI: Acute liver injury; ALT: Alanine transaminase; AST: Aspartate transaminase; CRP: C-reactive protein; GGT: Gamma-glutamyl transferase; LDH: Lactate dehydrogenase; LI: Liver injury; CSS: Cytokine storm syndrome; IL: Interleukin; ESR: Equivalent series resistance; TNF-α: Tumor necrosis factor-α; PLT: Platelet; Hb: Hemoglobin.