Future therapeutic implications of new molecular mechanism of colorectal cancer

doi:10.3748/wjg.v29.i16.2359

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Apr 28, 2023 (publication date) through May 18, 2024

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Apr 28, 2023; 29(16): 2359-2368
Published online Apr 28, 2023. doi: 10.3748/wjg.v29.i16.2359

Table 1 Identification of ataxia-telangiectasia mutated, anoctamin 5, adenomatous polyposis coli, and tumor protein 53 expression in pan-cancer samples

Cancer type	APC		TP53		ATM		ANO5
Cancer type	LogFC	P value	LogFC	P value	LogFC	P value	LogFC	P value
BLCA	-0.28889	0.005445	0.314908	0.032102	-0.27112	0.002207	-0.75984	5.46E-07
BRCA	-0.37268	1.46E-15	0.070558	0.261271	-0.41783	2.30E-16	-0.26734	2.03E-17
CHOL	0.798977	4.07E-06	2.043449	1.51E-07	0.718097	8.17E-06	-0.08998	0.123426
COAD	-0.57688	2.42E-15	0.505369	4.40E-09	0.086761	0.429393	-1.16109	3.06E-24
ESCA	0.134442	0.480134	0.792589	0.011648	-0.0696	0.629714	-0.81744	0.003288
GBM	-1.01588	0.000957	2.388451	0.000173	0.016551	0.761476	-1.26367	0.001745
HNSC	-0.18476	0.004628	-0.08774	0.958273	0.116251	0.114312	-0.82404	7.30E-09
KICH	-0.32313	0.003139	-0.63636	1.15E-07	-0.42688	1.83E-05	0.889727	7.05E-07
KIRC	-0.12313	0.033897	0.452895	2.19E-16	0.476935	2.14E-16	-1.43405	4.66E-34
KIRP	-0.34452	1.85E-05	0.784867	3.85E-12	0.110608	0.113455	-0.50628	2.70E-09
LIHC	0.253395	8.34E-06	0.41186	5.80E-06	0.187905	0.000776	0.070468	0.537737
LUAD	-0.4475	1.24E-13	0.430958	3.79E-09	0.14328	0.135749	-0.46868	9.13E-13
LUSC	-0.51847	1.39E-15	0.467462	0.000189	-0.14078	0.016441	-0.73565	5.71E-25
PRAD	-0.17991	0.011276	0.193039	0.000387	-0.12553	0.049659	-0.89276	6.11E-19
READ	-0.71729	3.89E-05	0.638392	0.007547	-0.18753	0.144797	-1.5861	1.99E-07
STAD	0.025202	0.628002	0.660337	1.23E-06	0.321073	0.001535	-0.63734	2.77E-05
THCA	-0.36112	1.91E-13	0.320993	4.99E-12	-0.40106	1.15E-13	-0.89401	2.36E-26
UCEC	-0.34584	3.78E-06	0.552104	1.66E-08	-0.56028	9.35E-14	-0.63913	2.84E-15

BLCA: Bladder urothelial carcinoma; BRCA: Breast invasive carcinoma; CHOL: Cholangiocarcinoma; COAD: Colon adenocarcinoma; ESCA: Esophageal carcinoma; GBM: Glioblatoma; HNSC: Head and neck squamous cell carcinoma; KICH: Kidney chromophobe; KIRC: Kidney renal clear cell carcinoma; KIRP: Kidney renal papillary cell carcinoma; LIHC: Liver hepatocellular carcinoma; LUAD: Lung adenocarcinoma; LUSC: Lung squamous cell carcinoma; PRAD: Prostate adenocarcinoma; READ: Rectal adenocarcinoma esophageal; STAD: Stomach adenocarcinoma; THCA: Thyroid carcinoma; UCEC: Uterine corpus endometrial carcinoma; APC: Adenomatous polyposis coli; ANO5: Anoctamin 5; ATM: Ataxia-telangiectasia mutation; TP: Tumor protein.

Citation: Lu S, Jia CY, Yang JS. Future therapeutic implications of new molecular mechanism of colorectal cancer. World J Gastroenterol 2023; 29(16): 2359-2368
URL: https://www.wjgnet.com/1007-9327/full/v29/i16/2359.htm
DOI: https://dx.doi.org/10.3748/wjg.v29.i16.2359