Clinical outcomes of lenvatinib plus transarterial chemoembolization with or without programmed death receptor-1 inhibitors in unresectable hepatocellular carcinoma

Table 4 Adverse events, n (%)

AEs	Lenvatinib + TACE + PD-1		Lenvatinib + TACE
	All grades	Grade 3/4	All grades	Grade 3/4
Decreased appetite	19 (42.2)	3 (6.7)	7 (35.0)	2 (10.0)
Elevated AST	18 (40)	3 (6.7)	5 (25.0)	0 (0)
Decreased albumin	18 (40)	2 (4.4)	6 (30.0)	1 (5.0)
Fatigue	17 (37.8)	3 (6.7)	8 (40.0)	1 (5.0)
Diarrhoea	13 (28.9)	5 (11.1)	4 (20.0)	1 (5.0)
Hypertension	13 (28.9)	3 (6.7)	3 (15.0)	0 (0)
Elevated blood bilirubin	13 (28.9)	2 (4.4)	5 (25.0)	0 (0)
Decreased platelet count	13 (28.9)	2 (4.4)	5 (25.0)	1 (5.0)
Hypothyroidism	12 (26.7)	2 (4.4)	3 (15.0)	0 (0)
Abdominal pain	11 (24.4)	2 (4.4)	4 (20.0)	1 (5.0)
Elevated ALT	11 (24.4)	2 (4.4)	4 (20.0)	0 (0)
Rash	8 (17.8)	2 (4.4)	2 (10.0)	0 (0)
Decreased WBC	7 (15.6)	0 (0)	4 (20.0)	0 (0)
Vomiting	7 (15.6)	0 (0)	3 (15.0)	0 (0)
Hypocalcemia	6 (13.3)	0 (0)	5 (25.0)	0 (0)
Palmar-plantar erythrodysaesthesia	5 (11.1)	0 (0)	1 (5.0)	0 (0)
Nausea	4 (8.9)	0 (0)	4 (20.0)	0 (0)
Elevated WBC	4 (8.9)	0 (0)	3 (15.0)	0 (0)
Gingival bleeding	4 (8.9)	0 (0)	1 (5.0)	0 (0)
Gastrointestinal hemorrhage	4 (8.9)	1 (2.2)	0 (0)	0 (0)
Decreased weight	3 (6.7)	0 (0)	2 (10.0)	0 (0)
Dysphonia	3 (6.7)	0 (0)	2 (10.0)	0 (0)
Proteinuria	1 (2.2)	1 (2.2)	1 (5.0)	0 (0)

AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; WBC: White blood cell; AEs: Adverse events; PD-1: Programmed death receptor-1; TACE: Transarterial chemoembolization.