Review
Copyright ©The Author(s) 2023.
World J Gastroenterol. Jan 7, 2023; 29(1): 43-60
Published online Jan 7, 2023. doi: 10.3748/wjg.v29.i1.43
Table 2 Summary of the studies that evaluated radiomics models to predict genetic profile in patients with hepatocellular cholangiocarcinoma
Ref.
Country
n
Imaging modality
Endpoint
Segmentation
ROI/VOI
No. of readers
Main results
Validation
Xia et al[98], 2018China38CTAssociation with gene expression profileManual, intratumoralROI1Individual textural features predicted gene modulesNo
Wu et al[44], 2022ChinaTraining: 120. Validation: 52CTKi-67 expressionManual, intratumoralVOI2AUC: 0.85 (training), 0.74 (validation)Internal
Li et al[45], 2019China83MRIKi-67 expressionManual, intratumoralROI2Some features were associated, no modelNo
Ye et al[47], 2019China89MRIKi-67 expressionManual, intratumoralVOI2C-index: 0.878No
Fan et al[46], 2021ChinaTraining: 103. Validation: 48MRIKi-67 expressionManual, intratumoralVOI2AUC: 0.88 (training), 0.80 (validation)Internal
Hu et al[48], 2022ChinaTraining: 87. Validation: 21MRIKi-67 expressionManual, intratumoralROI1AUC: 0.90 (training), 0.83 (validation)Internal
Wang et al[50], 2019China78MRICK19 positivityManual, intra- and peritumoralROI1AUC: 0.76No
Chen et al[51], 2021ChinaTraining: 102. Validation: 19MRICK19 positivityManual, intratumoralROI2AUC: 0.82 (training), 0.78 (external validation)Internal and external
Yang et al[52], 2021China (multi-center)Training: 143. Validation: 75MRICK19 positivityManual, intratumoralROI2AUC: 0.85 (training), 0.79 (external validation)Internal and external
Wu et al[55], 2019China63CTP53 mutation statusManual, intratumoralROI2AUC: 0.62-0.79No
Li et al[99], 2022China92MRIGene signatures associated with disease recurrenceManual, intratumoralROI2MRI radiomics features could help quantify GOLM1, SETD7, and RND1 expression levelsInternal
Liao et al[56], 2022ChinaTraining: 86. Validation: 46CTSomatic mutations of the PI3K signaling pathwayManual, intratumoral and peritumoralVOI2AUC: 0.74 (training), 0.73 (external validation)Internal and external
Che et al[60], 2022ChinaTraining: 69. Validation: 30CTβ-arrestin1 phosphorylationManual, intratumoralROI1AUC: 0.89 (training), 0.74 (validation)Internal