Cystic fibrosis transmembrane conductance regulator prevents ischemia/reperfusion induced intestinal apoptosis via inhibiting PI3K/AKT/NF-κB pathway

Figure 5 Cystic fibrosis transmembrane conductance regulator protects the intestinal cell from apoptosis induced by ischemia/ reperfusion by inhibiting PI3K/AKT/NF-κB pathway in vivo. A: Representative Western blotting and quantification data for cell apoptotic proteins Bcl-2 and Bax at different time after the ischemia/reperfusion (I/R) treatment, ^bP < 0.001 vs control (n = 3); B: Representative Western blotting and quantification data for PI3K, p-AKT^ser473, p-AKT^Thr308, and NF-κB P65 at different time after I/R treatment, ^aP < 0.01 and ^bP < 0.001 vs control (n = 3); C: Representative Western blotting and quantification data for cell apoptotic proteins Bcl-2 and Bax after the FSK treatment in I/R treatment animal model, ^aP < 0.01 and ^bP < 0.001 vs control (n = 3); D: Representative Western blotting and quantification data for PI3K, p-AKT^ser473, p-AKT^Thr308, and NF-κB P65 after FSK treatment in the I/R treatment animal model. Data are presented as mean ± SD. ^aP < 0.01 and ^bP < 0.001 vs control (n = 3).