Current and future perspectives on acute-on-chronic liver failure: Challenges of transplantation, machine perfusion, and beyond

Figure 1 Suggested flowchart on when to accept a non-ideal donor organ offer for transplantation in the acute-on-chronic liver failure setting. In this scenario, the coexistence of additional risk factors and the real-time change in organ failures are key components in deciding to proceed with transplantation. ACLF: Acute-on-chronic liver failure.