Clinical features and long-term outcomes of patients with colonic oligopolyposis of unknown etiology

Table 3 Malignancies in first-degree relatives of patients with colonic adenomatous polyposis of unknown etiology

Type of cancer in FDR	Number of cases (Total = 113)	Percentage (%)
CRC	25	22.1
Breast	20	17.6
Prostate	14	12.3
Non-melanoma skin cancer	10	8.8
Lung	8	7.0
Gastric	4	3.5
Bladder/Ureter	4	3.5
Brain	4	3.5
Renal	3	2.6
Melanoma	3	2.6
Cervical	3	2.6
Pancreas	2	1.7
Unknown type	2	1.7
Leukemia	2	1.7
Ovarian	2	1.7
Thyroid	2	1.7
Lymphoma	1	0.8
Liver	1	0.8
Malignant meningioma	1	0.8
Esophageal	1	0.8
Liposarcoma	1	0.8

54 patients reported a family history of cancer. Highest frequencies were noted for CRC (22.1%), Breast (17.6%) and Prostate (12.3%). 10 patients (18.5%) had 2 FDRs, 8 patients (14.8%) had 3 FDRs, 1 patient (1.9%) had 4 FDRs, 4 patients (7.4%) had 5 FDRs and 1 patient (1.9%) had 7 FDRs with any malignancy. FDR: First-degree relative; CRC: Colorectal cancer.