Clinical features and long-term outcomes of patients with colonic oligopolyposis of unknown etiology

Table 2 Genes sequenced in the colonic adenomatous polyposis of unknown etiology cohort

Gene name	Number of patients tested	Percentage (%)
APC	70	100
MUTYH (full seq.)	53	75.7
MLH1	43	61.4
MSH2	43	61.4
MSH6	42	60.0
PMS2	42	60.0
EPCAM	41	58.6
CHEK2	39	55.7
TP53	39	55.7
BMPR1A	38	54.3
CDH1	38	54.3
PTEN	38	54.3
SMAD4	38	54.3
STK11	38	54.3
GREM1	36	51.4
POLD1	36	51.4
POLE	36	51.4
ATM	33	47.1
AXIN2	28	40.0
MUTYH (Y179C and G396D mutations only)	17	24.3
NTHL1	15	21.4
MSH3	13	18.6
BLM	7	10.0
GALNT12	7	10.0
RPS20	4	5.7
MLH3	3	4.3
RNF43	1	1.4

Colorectal cancer related genes sequenced in the colonic adenomatous polyposis of unknown etiology cohort. All had at least APC and MUYTH sequenced. Full list of genes tested in Supplementary Table 1.