Pancreatic acinar cell carcinoma: A comprehensive review

doi:10.3748/wjg.v28.i40.5827

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Oct 28, 2022 (publication date) through May 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2022; 28(40): 5827-5844
Published online Oct 28, 2022. doi: 10.3748/wjg.v28.i40.5827

Table 1 Immunohistochemical profile from the differential diagnosis

Tumor type	PCK	Trypsin/chymotrypsin/BCL-10	BCL-10	B-Catenin	Synaptophysin	Chromogranin	Others
ACC	+	+	+	+/-	-/+	-/+	Amylase. Lipase. PAS
PDAC	+	-	-	-	-	-	P53, DPC4 loss
SPN	-/+	-	-	+¹	-	-	PR, CD56, Alpha 1-antitrypsin
PanNET	+	-	-	-	+	+	CD56, PAX8³, ISL1³
PBL	+	+	-	+²	-	-	Alpha fetoprotein, CEA

¹Nuclear.

²Nuclear/Cytoplasmic and positive in squamous morules.

³PAX8 and ISL1 are specific markers for PanNETs.

ACC: Acinar cell carcinoma; PCK: Pancytokeratin; PanNET: Pancreatic neuroendocrine tumors; PBL: Pancreatoblastoma; SPN: Solid pseudopapillary neoplasm; PDAC: Pancreatic ductal carcinoma; PAS: Periodic acid-Schiff; ISL 1: Islet 1; CEA: Carcinoembryonic antigen.

Citation: Calimano-Ramirez LF, Daoud T, Gopireddy DR, Morani AC, Waters R, Gumus K, Klekers AR, Bhosale PR, Virarkar MK. Pancreatic acinar cell carcinoma: A comprehensive review. World J Gastroenterol 2022; 28(40): 5827-5844
URL: https://www.wjgnet.com/1007-9327/full/v28/i40/5827.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i40.5827