Heterogeneity of immune control in chronic hepatitis B virus infection: Clinical implications on immunity with interferon-α treatment and retreatment

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2022; 28(40): 5784-5800
Published online Oct 28, 2022. doi: 10.3748/wjg.v28.i40.5784

Table 3 Host genetic variants associated with interferon-α therapy[43,44,74-78,91]

Gene ontology	Gene	Genetic determinants (SNP/Hap/CNVs)
HLA	HLA-DP	rs3077, rs9277535
	HLA-DQA1-DQB1-DRB1	0302-0303-*09
	HLA-DQB1	*0303
	HLA-DRB1	*08
	HLA-A, B, C	1101-4601-*0102
Cytokines	IL-28B	A-C¹,rs8099917, rs12979860, rs12980275
Others	CYP24A1	rs2248359
	CYP27B1	rs10877012, rs4646536
	G3BP2	rs3821977
	OAS	G-T-G-A², C-C-T-A³, C-C-C-A⁴, A-C-T-A⁵
	OAS3	rs2072136
	PRELID2	rs371991
	STAT4	rs7574865
	TRAPPC9	rs78900671
	VDBP	rs7041
	VDR	rs1544410, rs731236, rs11568820, rs10735810

Haplotypes:

¹A-C, rs12980275-rs12979860.

²G-T-G-A, rs3177979-rs1293747-rs4767043-rs10849829.

³C-C-T-A, rs2285934-rs2072138-rs2072136-rs10849829.

⁴C-C-C-A, rs2285934- rs2072138-rs2072136-rs10849829.

⁵A-C-T-A, rs2285934-rs2072138-rs2072136-rs10849829.

SNPs/Hap/CNVs: Single nucleotide polymorphisms/Haplotype/Copy number variations; HLA: Human leukocyte antigen.

Citation: Yin GQ, Chen KP, Gu XC. Heterogeneity of immune control in chronic hepatitis B virus infection: Clinical implications on immunity with interferon-α treatment and retreatment. World J Gastroenterol 2022; 28(40): 5784-5800
URL: https://www.wjgnet.com/1007-9327/full/v28/i40/5784.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i40.5784

Yin GQ, Chen KP, Gu XC. Heterogeneity of immune control in chronic hepatitis B virus infection: Clinical implications on immunity with interferon-α treatment and retreatment. World J Gastroenterol 2022; 28(40): 5784-5800 [PMID: 36353205 DOI: 10.3748/wjg.v28.i40.5784]

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