Timing of endoscopic retrograde cholangiopancreatography in the treatment of acute cholangitis of different severity

Table 4 Univariate and multivariate analyses of the factors associated with 30-d mortality

Variables		Univariate analysis		Multivariate analysis
		OR (95%CI)	P value	OR (95%CI)	P value
Age	≥ 75 yr	1.772 (0.393-7.991)	0.456
	< 75 yr
		Reference
Common bile duct stones	Yes	0.254 (0.056-1.146)	0.075
	No
		Reference
Malignant biliary obstruction	Yes	6.817 (1.494-31.109)	0.013	7.718 (0.664-89.660)	0.102
	No
		Reference
Fever, BT ≥ 39 °C	Yes	1.045 (0.124-8.777)	0.968
	No
		Reference
Abnormal WBC count	Yes	1.789 (0.345-9.289)	0.489
	No
		Reference
Hyperbilirubinemia, ≥ 5 mg/dL	Yes	1.382 (0.307-6.228)	0.673
	No
		Reference
Hepatic dysfunction, PT-INR > 1.5	Yes	8.896 (1.645-48.119)	0.011	2.257 (0.275-18.553)	0.449
	No
		Reference
Hematological dysfunction, PLT < 100 × 103/µL	Yes	4.885 (0.919-25.649)	0.063
	No
		Reference
Renal dysfunction, Cr > 2.0 mg/dL	Yes	4.548 (0.862-23.998)	0.074
	No
		Reference
Respiratory dysfunction, PaO2/FiO2 ratio > 300	Yes	10.517 (2.284-48.431)	0.003	1.644 (0.172-15.676)	0.666
	No
		Reference
Neurological dysfunction, conscious disturbance	Yes	15.094 (3.241-70.298)	0.001	2.773 (0.380-20.238)	0.315
	No
		Reference
Cardiovascular dysfunction1	Yes	18.750 (3.990-88.112)	< 0.001	17.756 (0.994-317.241)	0.050
	No
		Reference
Severity of AC	Grade III	18.732 (2.239-156.728)	0.007	3.603 (0.274-47.356)	0.329
	Grade II + I
		Reference
ICU admission	Yes	7.326 (1.373-39.101)	0.02	2.463 (0.204-29.703)	0.478
	No
		Reference
Time to ERCP	Every 1-d delay	1.950 (1.252-3.038)	0.003	2.081 (1.154-3.753)	0.015

¹Defined as hypotension requiring dopamine ≥ 5 µg/kg per min, or any dose of norepinephrine. AC: Acute cholangitis; BT: Body temperature; ERCP: Endoscopic retrograde cholangiopancreatography; ICU: Intensive care unit; PT/INR: Prothrombin time/international normalized ratio; WBC: White blood cell count.