Timing of endoscopic retrograde cholangiopancreatography in the treatment of acute cholangitis of different severity

Table 3 Primary and secondary outcomes

Outcomes	Total	Time to ERCP divided by 24 h			Time to ERCP divided by 48 h
		ERCP ≤ 24 h	ERCP > 24 h	P value	ERCP ≤ 48 h	ERCP > 48 h	P value
Overall	n = 683	n = 134	n = 549		n = 314	n = 369
30-d mortality, n (%)	7 (1.02)	0	7 (1.3)	0.356	0	7 (1.9)	0.017
ICU admission, n (%)	37 (5.4)	15 (11.2)	22 (4)	0.001	22 (7.0)	15 (4.07)	0.091
LOHS in d1	7 (5-10)	6 (4-10)	7 (5-10)	0.018	6 (4-9)	8 (6-11)	< 0.001
30-d readmission, n (%)	87 (12.7)	16 (11.9)	71 (12.9)	0.757	40 (12.7)	47 (12.7)	0.999
Grade III AC	n = 170	n = 39	n = 131		n = 72	n = 98
30-d mortality, n (%)	6 (3.5)	0	6 (4.6)	0.338	0	6 (6.1)	0.039
ICU admission, n (%)	26 (15.3)	12 (9.0)	14 (2.6)	0.002	16 (22.2)	10 (10.2)	0.031
LOHS in d1	7 (7-14)	10 (6-16.5)	9 (7-12)	0.637	9 (6-15)	9 (7-12)	0.448
30-d readmission, n (%)	23 (13.5)	4 (3)	19 (14.5)	0.602	10 (13.9)	13 (13.3)	0.906
Grade II AC	n = 179	n = 39	n = 140		n = 88	n = 91
30-d mortality, n (%)	0	0	0	-	0	0	-
ICU admission, n (%)	5 (2.8)	2 (5.1)	3 (2.1)	0.299	3 (3.4)	2 (2.2)	0.679
LOHS in d1	7 (5-10)	6 (4-9.5)	7 (5.8-10)	0.047	6 (4.8-9)	8 (6-11)	0.001
30-d readmission, n (%)	24 (13.4)	4 (10.3)	20 (14.3)	0.514	8 (9.1)	16 (17.6)	0.096
Grade I AC	n = 334	n = 56	n = 278		n = 154	n = 180
30-d mortality, n (%)	1 (0.3)	0	1 (0.36)	1	0	1 (0.56)	1
ICU admission, n (%)	6 (1.8)	1 (1.8)	5 (1.8)	1	3 (1.9)	3 (1.7)	1
LOHS in d1	6 (5-9)	6 (4-8.3)	7 (5-9.8)	0.005	6 (4-7)	7 (6-11)	< 0.001
30-d readmission, n (%)	40 (12)	8 (14.3)	32 (11.5)	0.56	22 (14.3)	18	0.229

¹Expressed as median (interquartile range). AC: Acute cholangitis; ERCP: Endoscopic retrograde cholangiopancreatography; ICU: Intensive care unit; LOHS: Length of hospital stay.