Timing of endoscopic retrograde cholangiopancreatography in the treatment of acute cholangitis of different severity

Table 2 Characteristics of endoscopic retrograde cholangiopancreatography

Patient characteristics	Total, n = 683	Time to ERCP divided by 24 h			Time to ERCP divided by 48 h
		ERCP ≤ 24 h, n = 134	ERCP > 24 h, n = 549	P value	ERCP ≤ 48 h, n = 314	ERCP > 48 h, n = 369	P value
Time to ERCP in h1	53.8 (28.4-90.7)	17.7 (9.0-20.4)	67.6 (43.6-98.9)	-	26.0 (18.8-40.1)	88.5 (67.2-114.6)
Indications of ERCP, n (%)
Common bile duct stones	508 (74.4)	107 (79.9)	401 (73)	0.106	256 (81.5)	252 (68.3)	< 0.001
Malignant obstruction	70 (10.2)	7 (5.2)	63 (11.5)	0.032	19 (6.1)	51 (13.8)	< 0.001
Stent dysfunction	61 (8.9)	8 (6.0)	53 (9.7)	0.180	17 (5.4)	44 (11.9)	0.003
Benign stricture	31 (4.5)	8 (6.0)	23 (4.2)	0.375	15 (4.8)	16 (4.3)	0.783
Others	13 (1.9)	4 (3.0)	9 (1.6)	0.296	7 (2.2)	6 (1.6)	0.565
Treatment during ERCP, n (%)
ES	558 (81.7)	112 (83.6)	446 (81.2)	0.529	269 (85.7)	289 (78.3)	0.013
EPBD	5 (0.7)	0	5 (0.9)	0.589	2 (0.6)	3 (0.8)	1
Stone retrieval	502 (73.5)	108 (80.6)	394 (71.8)	0.038	250 (79.6)	252 (68.3)	0.001
Clearance without stone	37 (5.4)	5 (3.7)	32 (5.8)	0.336	16 (5.1)	21 (5.7)	0.732
Removal of old stents	60 (8.8)	6 (4.5)	54 (9.8)	0.049	17 (5.4)	43 (11.7)	0.004
Stent insertion	187 (27.4)	35 (26.1)	152 (27.7)	0.715	70 (22.3)	117 (31.7)	0.006
Biliary stricture dilatation	7 (1.0)	1 (0.7)	6 (1.1)	1	1 (0.3)	6 (1.6)	0.132
Others	3 (0.4)	0	3 (0.5)	1	0	3 (0.8)	0.254
ERCP failure, n (%)	7 (1.0)	0	7 (1.3)	0.356	1 (0.3)	6 (1.6)	0.132

¹Expressed as median (interquartile range). EPBD: Endoscopic papillary balloon dilation; ERCP: Endoscopic retrograde cholangiopancreatography; ES: Endoscopic sphincterotomy.