Noncoding RNAs as additional mediators of epigenetic regulation in nonalcoholic fatty liver disease

Table 3 Relevant dysregulated circular RNAs associated with alterations in liver metabolism and nonalcoholic fatty liver disease

circRNA	Expression level	Main functional and pathophysiological effects	Ref.
circRNA_0046367	↑	Inhibits hepatic steatosis by preventing hepatotoxicity of lipid peroxidation	[148]
circRNA_0046366	↑	Inhibits hepatic steatosis through miR-34a/PPARα	[149]
circRNA_021412	↑	Associated with hepatic steatosis	[150]
circScd1	↓	Affects steatosis on NAFLD via JAK2/STAT5 signaling pathways	[151]
hsa_circ_0048179	↓	Attenuates free fatty acid-induceded steatosis by sponging of miR-188-3p in vitro	[152]
mmu_circRNA_29981	↑	Regulatory role in NASH mousee model	[153]
Circ_0057558	↑	Involved in lipogenesis	[156]
		Promotes nonalcoholic fatty liver disease by sponging miR-206
SCAR	↓	Correlates with steatosis-to-NASH progression	[157]
		In vivo, targeting circRNA SCAR alleviates HFD-induced cirrhosis and insulin resistance

circRNAs: Circular RNAs; HCC: Hepatocellular carcinoma; HFD: High-fat diet; JAK2: Janus Kinase 2; NAFLD: Nonalcoholic fatty liver disease; NASH: Nonalcoholic steatohepatitis; PPARα: Peroxisome proliferator-activated receptor α; STAT5: Signal transducer and activator of transcription 5.