Impact of adalimumab on disease burden in moderate-to-severe ulcerative colitis patients: The one-year, real-world UCanADA study

Table 2 Patient Health Questionnaire–9 items at week 8 and week 52/final visit

Outcome	ITT			Completers
	Baseline (n = 94)	Week 8 (n = 94)	Week 52/final visit (n = 73)	Baseline (n = 48)	Week 8 (n = 48)	Week 52/final visit (n = 47)
PHQ-9 total score
n	94	82	65	48	43	44
mean ± SD	8.8 (6.3)	6.8 (5.3)	6.5 (5.6)	8.2 (6.7)	5.8 (5.6)	4.6 (4.3)
Median	8.0	6.0	5.0	5.0	5.0	3.0
Min, Max	0.0, 26.0	0.0, 26.0	0.0, 22.0	1.0, 26.0	0.0, 26.0	0.0, 15.0
Change from baseline
n		82	65		43	44
mean ± SD		-2.2 (6.1)	-2.4 (7.1)		-2.5 (6.1)	-3.4 (6.8)
P value		0.002	0.008		0.010	0.002
PHQ-9 category, n (%)
Minimal	35 (37.2)	31 (37.8)	28 (43.1)	23 (47.9)	21 (48.8)	25 (56.8)
Mild	23 (24.5)	30 (36.6)	18 (27.7)	8 (16.7)	14 (32.6)	11 (25.0)
Moderate	18 (19.1)	14 (17.1)	11 (16.9)	9 (18.8)	4 (9.3)	7 (15.9)
Moderately severe	11 (11.7)	4 (4.9)	7 (10.8)	4 (8.3)	2 (4.7)	1 (2.3)
Severe	7 (7.4)	3 (3.7)	1 (1.5)	4 (8.3)	2 (4.7)	0 (0.0)
P value		0.280	0.681		0.610	0.542
PHQ-9: Yellow flag category, n (%)
	36 (38.3)	21 (25.6)	19 (29.2)	17 (35.4)	8 (18.6)	8 (18.2)
P value		0.028	0.083		0.021	0.059
PHQ-9: Red flag category, n (%)
Yes	18 (19.1)	7 (8.5)	8 (12.3)	8 (16.7)	4 (9.3)	1 (2.3)
P value		0.013	0.134		0.180	0.034

The yellow flag category was defined as the proportion of patients with a Patient Health Questionnaire–9 total score ≥ 10, and the red flag category was defined as patients with severe depressive symptoms. ITT: Intent-to-treat; Max: Maximum; Min: Minimum; PHQ-9: Patient Health Questionnaire–9 items.