Impact of adalimumab on disease burden in moderate-to-severe ulcerative colitis patients: The one-year, real-world UCanADA study

Table 1 Baseline patient and disease characteristics

Characteristics		N	n (%) or mean ± SD
Age		94	42.5 (15.3)
Gender	Male	94	56 (59.6)
BMI (kg/m2)		91	25.4 (4.5)
Race	American Indian/Alaska Native	94	1 (1.1)
	Asian		5 (5.3)
	White		88 (93.6)
Employment status	Disability		2 (2.1)
	Employed (fulltime, part time < 35 h/week)		63 (67.0)
	Homemaker		3 (3.2)
	Retired		12 (12.8)
	Student		6 (6.4)
	Temporary leave of absence		1 (1.1)
	Unemployed		6 (6.4)
	Unknown		1 (1.1)
Tobacco use	Current smoker	94	2 (2.1)
	Former smoker		34 (36.2)
	Never smoked		55 (58.5)
	Unknown		3 (3.2)
Alcohol use	Non-drinker	94	20 (21.3)
	Ex-drinker		5 (5.3)
	Light (less than 2 drinks per day)		61 (64.9)
	Moderate (2-4 drinks per day)		5 (5.3)
	Unknown		3 (3.2)
Age at UC diagnosis (yr)		98	34.5 (15.3)
Disease duration (yr)		98	7.9 (8.0)
Family history of UC	No	98	59 (60.2)
	Yes		20 (20.4)
	Unknown		19 (19.4)
Montreal classification of extent of UC	E2	97	55 (56.7)
(prior 3 mo)	E3		42 (43.3)
Mayo Endoscopic Subscore	1	90	1 (1.1)
(prior 3 mo)	2		66 (73.3)
	3		23 (25.6)
Endoscopy (prior 6 mo)	Yes	98	91 (92.9)
UC-related ED visit (prior 6 mo)	Yes	98	13 (13.3)
UC-related hospitalization (prior 6 mo)	Yes	98	12 (12.2)
Previous biologic use	Yes	44	5 (11.4)
Medication use:	Corticosteroids	98	63 (64.3)
Since UC diagnosis to prior 6 mo	Imuran (azathioprine)		37 (37.8)
	6-MP		8 (8.2)
	5-ASA		83 (84.7)
	Methotrexate		5 (5.1)
	Cyclosporine		1 (1.0)
Medication use:	Corticosteroids	98	61 (62.2)
Since prior 6 mo to current	Imuran (azathioprine)		39 (39.8)
	6-MP		5 (5.1)
	5-ASA		67 (68.4)
	Methotrexate		8 (8.2)
	Cyclosporine		0 (0.0)

Montreal classification of extent of UC: E2 = left sided (distal) ulcerative colitis, E3 = extensive (pancolitis) ulcerative colitis; Mayo endoscopic subscore: 0 = normal or inactive disease, 1 = mild disease, 2 = moderate disease, 3 = severe disease; 5-ASA: 5-aminosalicylic acid; 6-MP: Mercaptopurine; BMI: Body mass index; ED: Emergency department; UC: Ulcerative colitis.