Preoperative contrast-enhanced computed tomography-based radiomics model for overall survival prediction in hepatocellular carcinoma

Table 2 Univariate Cox regression analysis in the training cohort

Variables	Univariate Cox regression analysis
	HR	95%CI	P value
Age, yr	0.993	0.971-1.016	0.545
Sex (male vs female)	0.789	0.376-1.657	0.532
Alcohol abuse (present vs absent)	1.133	0.692-1.854	0.620
Tumor number (multiple vs single)	1.060	0.594-1.892	0.843
Tumor diameter, cm (> 5 vs ≤ 5)	1.147	0.681-1.934	0.606
MVI (present vs absent)	1.506	0.921-2.461	0.102
Cirrhosis (present vs absent)	1.112	0.404-3.063	0.837
DB, μmol/L (> 6.8 vs ≤ 6.8)	1.551	0.766-3.140	0.223
ALB, g/L (> 35 vs ≤ 35)	0.677	0.388-1.181	0.169
GGT, U/L (> 50 vs ≤ 50)	1.482	0.879-2.499	0.140
ALT, U/L (> 40 vs ≤ 40)	1.671	1.002-2.787	0.049
AFP, ng/mL (> 200 vs ≤ 200)	2.202	1.340-3.619	0.002
HBsAg (positive vs negative)	1.013	0.516-1.991	0.969
NLR (> 2.31 vs ≤ 2.31)	3.160	1.901-5.251	< 0.001
Radiomics signature	10.315	3.829-27.786	< 0.001

HR: Hazard ratio; MVI: Microvascular invasion; DB: Direct bilirubin; ALB: Albumin; GGT: Gamma-glutamyl transpeptidase; ALT: Alanine transaminase; AFP: Alpha fetoprotein; HBsAg: Hepatitis B surface antigen; NLR: Neutrophil-to-lymphocyte ratio.