Cumulative incidence and risk factors for pouch adenomas associated with familial adenomatous polyposis following restorative proctocolectomy

Table 3 Risk factors associated with pouch adenoma-free survival

Variable	Univariate analysis		Multivariable analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age	0.97 (0.93-1.01)	0.12
Sex (male)	1.46 (0.62-3.44)	0.39
No. of colorectal polyps (≥ 1000)	2.80 (1.18-6.63)	0.019	2.49 (1.04-5.96)	0.041
Time interval after IPAA	0.996 (0.99-1.003)	0.29
Mucosectomy	1.54 (0.56-4.24)	0.40
Gastric polyps	1.73 (0.64-4.68)	0.28
Duodenal adenoma	2.31 (0.99-5.41)	0.54	2.08 (0.88-4.93)	0.10
Spigelman stage		0.15
I-II	2.27 (0.92-5.55)	0.07
III-IV	2.46 (0.73-8.25)	0.14
Desmoid tumor	0.82 (0.28-2.44)	0.72
NSAID use	0.29 (0.04-2.13)	0.22
Colorectal cancer	0.58 (0.25-1.37)	0.21

IPAA: Ileal pouch anal anastomosis; NSAIDs: Nonsteroidal anti-inflammatory drugs; HR: Hazard ratio; CI: Confidence interval.