Melatonin prevents oxidative stress, inflammatory activity, and DNA damage in cirrhotic rats

doi:10.3748/wjg.v28.i3.348

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2022; 28(3): 348-364
Published online Jan 21, 2022. doi: 10.3748/wjg.v28.i3.348

Table 1 Activity of lipid peroxidation levels, antioxidant enzyme superoxide dismutase, and nitric oxide levels in the experimental groups

Groups	TBARS	SOD	NO₂/NO₃
CO	0.29 ± 0.01	2.62 ± 0.11	1.69 ± 0.08
CO + MLT	0.34 ± 0.02	2.43 ± 0.05	1.76 ± 0.09
BDL	3.43 ± 0.08^a	0.61 ± 0.05^a	5.53 ± 0.30^a
BDL + MLT	0.46 ± 0.01^b	2.30 ± 0.07^b	2.48 ± 0.36^b

^aP < 0.001: Significant increase in the bile duct ligation group in relation to the control and CO + melatonin groups.

^bP < 0.001: Significant reduction in the BDL + MLT group in relation to the BDL group.

CO: Control; MLT: Melatonin; BDL: Bile duct ligation; TBARS: Thiobarbituric acid reactive substances; SOD: Superoxide dismutase.

Citation: Colares JR, Hartmann RM, Schemitt EG, Fonseca SRB, Brasil MS, Picada JN, Dias AS, Bueno AF, Marroni CA, Marroni NP. Melatonin prevents oxidative stress, inflammatory activity, and DNA damage in cirrhotic rats. World J Gastroenterol 2022; 28(3): 348-364
URL: https://www.wjgnet.com/1007-9327/full/v28/i3/348.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i3.348