Comprehensive evaluation of microRNA as a biomarker for the diagnosis of hepatocellular carcinoma

doi:10.3748/wjg.v28.i29.3917

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Aug 7, 2022 (publication date) through Sep 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 7, 2022; 28(29): 3917-3933
Published online Aug 7, 2022. doi: 10.3748/wjg.v28.i29.3917

Table 6 Univariate analysis of real-time quantitative PCR results for comparison

miRNA	Wilcoxon Q-value	AUC	Specificity at 90% sensitivity	Comparison
hsa-miR-21-5p	0.00025^a	0.65	0.17	All HCC vs CLD
hsa-miR-423-5p	0.037^b	0.59	0.11
hsa-miR-320d	0.078	0.57	0.11
hsa-miR-652-3p	0.25	0.59	0.13	Early HCC vs cirrhosis

^aQ-value < 0.001.

^bQ-value < 0.05.

AUC: Area under the curve; CLD: Chronic liver disease; HCC: Hepatocellular carcinoma; miRNA: MicroRNA; miR: MicroRNA.

Citation: Malik J, Klammer M, Rolny V, Chan HLY, Piratvisuth T, Tanwandee T, Thongsawat S, Sukeepaisarnjaroen W, Esteban JI, Bes M, Köhler B, Swiatek-de Lange M. Comprehensive evaluation of microRNA as a biomarker for the diagnosis of hepatocellular carcinoma. World J Gastroenterol 2022; 28(29): 3917-3933
URL: https://www.wjgnet.com/1007-9327/full/v28/i29/3917.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i29.3917