Mechanistic and functional extrapolation of SET and MYND domain-containing protein 2 to pancreatic cancer

Table 2 SET and MYND domain-containing protein 2 involvement in human cancers

Cancer type	Findings	Ref.
Acute lymphoblastic leukemia	SMYD2 overexpression; worse OS and EFS; higher WBC counts; a higher percentage of high-risk disease; prognostic factor	[38]
Bladder cancer	Higher expression of SMYD2; promotes cell cycle progression of cancer cells; methylation of RB	[23]
Breast cancer	SMYD2 overexpression; worse RFS; prognostic factor	[107]
	SMYD2 overexpression; poor survival	[30]
Cervical cancer	Higher expression of SMYD2; worse OS; advanced FIGO stage; larger tumor size; poor prognosis	[41]
Chronic lymphocytic leukemia	Higher expression of SMYD2; high WBC counts; complex karyotype; tumor progression	[108]
Clear cell renal cell carcinoma	SMYD2 overexpression; worse OS and DFS; high TNM stage; early tumor relapse	[46]
Colon cancer	SMYD2 overexpression; upregulation MDR1/P-glycoprotein; poor prognosis; enhances oxaliplatin resistance	[31]
Colorectal cancer	SMYD2 overexpression; activates the Wnt/β-catenin pathway; worse OS and DFS; worse oncologic outcomes	[36]
Esophageal squamous cell carcinoma	Higher expression of SMYD2; worse OS; enhances venous invasion; higher pT category and recurrence	[34]
Gastric cancer	SMYD2 overexpression correlates with larger tumor size; aggressive invasion; more lymph node metastasis; recurrence; poor OS	[33]
Hematopoietic leukemias	Higher expression of SMYD2; promote Wnt-β-Catenin signaling; poor OS	[39]
Hepatocellular carcinoma	SMYD2 overexpression correlates with tumor size; vascular invasion; differentiation; TNM stage; worse OS; poor prognosis	[14]
HPV-unrelated, non-multiple head and neck cancer	Higher expression of SMYD2; worse OS; prognostic biomarker	[15]
Lower-grade gliomas	Poor OS; prognostic biomarker	[109]
Lung adenocarcinoma	Overexpressed SMYD2 correlates with shorter OS and DFS; promotes proliferation, migration, and invasion of cancer cells	[13]
Non-small cell lung cancer	Overexpressed SMYD2 enhances cisplatin resistance; downregulates the p53 pathway	[32]
Ovarian clear cell carcinoma	Shorter OS and DSS; prognostic biomarker	[43]
Pancreatic cancer	SMYD2 overexpression; methylation of MAPKAPK3; enhances precancerous lesions; poor OS	[16]
Papillary thyroid carcinoma	SMYD2 overexpression correlates with PTC progression; poor prognosis and DFS; worse clinical outcomes	[40]
Renal cell tumor	Low expression of SMYD2 correlates with shorter DSS and DFS; prognostic biomarker	[45]

SMYD2: SET and MYND domain-containing protein 2; OS: Overall survival; EFS: Event-free survival; DFS: Disease-free survival; DSS: Disease-specific survival.