Combination approaches in hepatocellular carcinoma: How systemic treatment can benefit candidates to locoregional modalities

Table 2 Clinical trials approaching combination of systemic treatment and ablation enrolling, recruiting, or waiting for final results

Trial	Trial registration	Drug	Control	n	Disease stage	Local treatment	Expected termination	Primary end-point
CHECKMATE 9DX	NCT03383458	Nivolumab	Placebo	530	Early/intermediate	Surgery/Ablation	2025	Recurrence-free survival
KEYNOTE 937	NCT03867084	Pembrolizumab	Placebo	950	Early/intermediate	Surgery/Ablation	2025	Recurrence-free survival and overall survival
IMBRAVE 050	NCT04102098	Atezolizumab + Bevacizumab	Surveillance	662	Early/intermediate /advanced	Surgery/Ablation	2027	Recurrence-free survival
EMERALD-2	NCT03847428	Durvalumab + Bevacizumab	Placebo	888	Early/intermediate	Surgery/Ablation	2024	Recurrence-free survival