Fecal gene detection based on next generation sequencing for colorectal cancer diagnosis

Table 8 Comparison of pathogenic mutation sites in preoperative stools vs postoperative stools

Gene	Positive rate of pathogenic gene mutation sites		χ2	P value
	Preoperative feces	Postoperative stools
TP53	37.04% (10/27)	0	6.947	0.008
APC	11.11% (3/27)	0	0.804	0.370
KRAS	25.93% (7/27)	0	3.974	0.046
PIK3CA	3.70% (1/27)	5.26% (1/19)	Fisher exact test	1
FBXW7	3.70% (1/27)	0	Fisher exact test	1
GNAS	3.70% (1/27)	0	Fisher exact test	1
PTEN	3.70% (1/27)	0	Fisher exact test	1
ABL1	3.70% (1/27)	0	Fisher exact test	1
PDGFRA	3.70% (1/27)	0	Fisher exact test	1
BRAF	0	5.26% (1/19)	Fisher exact test	1
MPL	0	5.26% (1/19)	Fisher exact test	1

Positive rate of pathogenic gene mutation site: The number of people with mutations corresponding to the pathogenic mutation sites of any gene/total number of sample.