Infliximab trough level combined with inflammatory biomarkers predict long-term endoscopic outcomes in Crohn’s disease under infliximab therapy

Table 2 Predictive indicators of endoscopic relapse in Crohn's disease patients with endoscopic remission

Variable	Week 14 (after initial IFX therapy), n = 93				Week 14 (after initial IFX therapy), n = 54
	Predict endoscopic relapse at week 54				Predict endoscopic relapse at week 108
	Univariate analysis		Multivariable analysis		Univariate analysis		Multivariable analysis
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
Median age in year, median (IQR)	0.997 (0.950-1.047)	0.904	—	—	1.028 (0.967-1.093)	0.381	—	—
Course in year, median (IQR)	1.054 (0.945-1.176)	0.346	—	—	1.065 (0.906-1.253)	0.444	—	—
Male sex, n (%)	0.478 (0.191-1.199)	0.116	—	—	0.700 (0.188-2.607)	0.595	—	—
Disease location, n (%)
L1 (terminal ileum)	0.413 (0.114-1.495)	0.178	—	—	1.158 0.117-11.454)	0.900	—	—
L2 (colon)	1.453 (0.430-4.908)	0.548	—	—	3.000 (0.341-26.427)	0.322	—	—
L3 (ileocolon)	—	—	—	—	—	—	—	—
L4 (upper digestive tract)	1.277 (0.452-3.612)	0.645	—	—	0.939 (0.215-4.113)	0.934	—	—
Disease behavior, n (%)
B1 (no)	—	—	—	—	—	—	—	—
B2 (stenosis)	0.889 (0.345-2.294)	0.808	—	—	0.600 (0.141-2.561)	0.490	—	—
B3 (penetration)	1.860 (0.658-5.264)	0.242	—	—	0.700 (0.188-2.607)	0.595	—	—
B2 (stenosis) + B3 (penetration)	—	—	—	—	—	—	—	—
Perianal diseases, n (%)	1.442 (0.562-3.696)	0.446	—	—	0.952 (0.259-3.502)	0.941	—	—
Previous medical therapy, n (%)	1.027 (0.386-2.736)	0.957			2.040 (0.481-8.650)	0.333
Previous surgical therapy, n (%)	0.926 (0.266-3.218)	0.903	—	—	—	—	—	—
Laboratory indicators, median (IQR)
Fecal calprotectin, μg/g	1.003 (1.002-1.005)	0.000	1.002 (1.001-1.004)	0.002	1.002 (1.001-1.004)	0.001	NS	NS
IFX trough level, μg/mL	0.650 (0.532-0.796)	0.000	0.666 (0.514-0.862)	0.002	0.470 (0.289-0.766)	0.002	0.466 (0.247-0.877)	0.018
White blood count, x 109/L	1.167 (0.921-1.478)	0.201	—	—	1.004 (0.636-1.586)	0.986	—	—
Hematoglobin, g/L	0.977 (0.954-1.000)	0.053	—	—	0.997 (0.957-1.038)	0.867	—	—
Platelet, x 109/L	1.006 (0.999-1.013)	0.081	—	—	1.001 (0.987-1.015)	0.904	—	—
Erythrocyte sedimentation rate, mm/h	1.073 (1.028-1.120)	0.001	NS	NS	1.035 (0.978-1.096)	0.239	—	—
Albumin, g/L	0.895 (0.800-1.002)	0.054	—	—	0.821 (0.667-1.010)	0.062	—	—
C-reactive protein, mg/dL	1.245 (1.080-1.435)	0.003	NS	NS	1.389 (1.070-1.804)	0.014	1.590 (1.007-2.510)	0.047

IFX: Infliximab; NS: Not significant; CI: Confidence interval; IQR: Interquartile range; OR: Odds ratio.