Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma

doi:10.3748/wjg.v28.i21.2302

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Jun 7, 2022 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2022; 28(21): 2302-2319
Published online Jun 7, 2022. doi: 10.3748/wjg.v28.i21.2302

Table 1 Clinicopathological characteristics of the study population illustrating the correlation for the percentage of CD3⁺, CD3⁺CD4⁺ and CD3⁺CD8⁺ cells expressing immune checkpoints present in oesophageal adenocarcinoma tumour tissue

Clinical factor	IC expression	Radiation dose	Spearman r	P value (two-tailed)
Lymphovascular invasion	PD-1 CD3⁺	0 Gy	0.6396022	0.046435
Clinical T stage	PD-L1 CD3⁺	0 Gy	0.6411189	0.024659
	PD-1 CD8⁺	2 Gy	-0.7000000	0.016471
	PD-L1 CD3⁺	2 Gy	0.7768986	0.004908
	TIM-3 CD3⁺	2 Gy	0.7171372	0.012993
	TIM-3 CD4⁺	2 Gy	0.7171372	0.012993
	TIM-3 CD8⁺	4 Gy	0.6963106	0.025293
Clinical N stage	PD-L1 CD4⁺	0 Gy	0.8568931	0.000370
	PD-1 CD4⁺	4 Gy	0.7311262	0.016282
	TIM-3 CD4⁺	4 Gy	0.6614951	0.037241
	TIM-3 CD8⁺	4 Gy	0.6614951	0.037241
Pathological T stage	TIGIT CD3⁺	2 Gy	-0.7395740	0.014492
	TIGIT CD3⁺	4 Gy	-0.8964215	0.006267
Pathological N stage	PD-L1 CD4⁺	0 Gy	0.6510135	0.041473
	PD-L1 CD8⁺	2 Gy	-0.6443043	0.044345
	TIGIT CD3⁺	2 Gy	-0.7471188	0.013014
	TIGIT CD4⁺	4 Gy	0.8981774	0.006011

Positive values indicate positive correlation, negative values indicate negative correlation. Spearman correlation. Only significant data shown. Spearman r = 0.40-0.59 moderate, 0.60-0.79 strong and 0.80-1.00 very strong. IC: Immune checkpoint.

Citation: Donlon NE, Davern M, O’Connell F, Sheppard A, Heeran A, Bhardwaj A, Butler C, Narayanasamy R, Donohoe C, Phelan JJ, Lynam-Lennon N, Dunne MR, Maher S, O’Sullivan J, Reynolds JV, Lysaght J. Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma. World J Gastroenterol 2022; 28(21): 2302-2319
URL: https://www.wjgnet.com/1007-9327/full/v28/i21/2302.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i21.2302