Gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced magnetic resonance imaging for evaluating fibrosis regression in chronic hepatitis C patients after direct-acting antiviral

Table 4 The area under receiver operating curve and cut-off value for liver cirrhosis and significant liver fibrosis at pre-sustained virological response and post-sustained virological response with contrast enhancement index, aspartate aminotransferase-to-platelet ratio index, Fibrosis-4 and liver stiffness measurement

	Ishak score ≥ 5		Ishak score ≥ 3
	Pre SVR	Post SVR	Pre SVR	Post SVR
CEI
AUROC (95%CI)	0.93 (0.74, 0.97)	0.87 (0.65, 0.97)	0.88 (0.79, 1.00)	0.87 (0.71, 1.00)
Cut-off value	1.58	1.59	1.71	1.68
LSM
AUROC (95%CI)	0.87(0.71, 1.00)	0.87(0.79, 1.00)	0.91(0.78, 1.00)	0.80(0.60,0.98)
Cut-off value	10.8	7.1	6.2	5.95
APRI
AUROC (95%CI)	0.89(0.72, 1.00)	0.89(0.74, 1.00)	0.83(0.64, 1.00)	N2
Cut-off value	1.05	0.241	0.39	N2
FIB-4
AUROC (95%CI)	0.92(0.80, 1.00)	0.92(0.79, 1.00)	0.80(0.58, 1.00)	N2
Cut-off value	1.78	1.281	0.87	N2

¹The cutoff values of aspartate aminotransferase-to-platelet ratio index (APRI) and Fibrosis-4 (FIB-4) or the diagnosis of liver cirrhosis decreased dramatically after sustained virological response (SVR).

²N: No diagnosis value of APRI or FIB-4 in patients with significant fibrosis after achieving SVR.

APRI: Aspartate aminotransferase-to-platelet ratio index; AUROC: Area under receiver operating curve; CEI: Contrast enhancement index; CI: Confidence interval; FIB-4: Fibrosis-4; LSM: Liver stiffness measurement; SVR: Sustained virological response.